Publication
HBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recycling
| dc.contributor.author | Kozlowska, Lucyna | |
| dc.contributor.author | Viegas, Susana | |
| dc.contributor.author | Scheepers, Paul T.J. | |
| dc.contributor.author | Duca, Radu C. | |
| dc.contributor.author | Godderis, Lode | |
| dc.contributor.author | Martins, Carla | |
| dc.contributor.author | Krzesimir, Ciura | |
| dc.contributor.author | Jagiello, Karolina | |
| dc.contributor.author | Silva, Maria João | |
| dc.contributor.author | Mahiout, Selma | |
| dc.contributor.author | Mārtiņsone, Inese | |
| dc.contributor.author | Matisāne, Linda | |
| dc.contributor.author | van Nieuwenhuyse, An | |
| dc.contributor.author | Puzyn, Tomasz | |
| dc.contributor.author | Sijko-Szpanska, Monika | |
| dc.contributor.author | Verdonck, Jelle | |
| dc.contributor.author | Santonen, Tiina | |
| dc.contributor.author | HBM4EU E-waste Study Team | |
| dc.date.accessioned | 2025-11-13T13:01:12Z | |
| dc.date.available | 2025-11-13T13:01:12Z | |
| dc.date.issued | 2025-02 | |
| dc.description.abstract | E-waste contains hazardous chemicals that may be a direct health risk for workers involved in recycling. We conducted an untargeted metabolomics analysis of urine samples collected from male e-waste processing workers to explore metabolic changes associated with chemical exposures in e-waste recycling in Belgium, Finland, Latvia, Luxembourg, the Netherlands, Poland, and Portugal. Questionnaire data and urine samples were obtained from workers involved in the processing of e-waste (sorting, dismantling, shredding, pre-processing, metal, and non-metal processing), as well as from controls with no known occupational exposure. Pre- and post-shift urine samples were collected and analysed using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-MS). A total of 32 endogenous urinary metabolites were annotated with a Variable Importance in Projection (VIP) above 2, indicating that e-waste recycling is mainly associated with changes in steroid hormone and neurotransmitter metabolism, energy metabolism, bile acid biosynthesis, and inflammation. The highest VIP was observed for dopamine-o-quinone, which is linked to Parkinson’s disease. These and other changes in metabolism in workers employed in the processing of e-waste need further verification in targeted studies. | eng |
| dc.description.abstract | Highlights: - Untargeted metabolomics is a novel tool to explore the effects of exposure; - E-waste recycling is connected to mixture exposure; - Exposure to a mixture of chemicals is associated with a multidirectional effect on metabolism; - Effects of exposure: inflammation, changes in hormones, neurotransmitters, bile acids, energy metabolism. | eng |
| dc.description.sponsorship | This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations and/or Ministries. In addition, the Finnish Work Environment fund provided funding (grant no. 200345). The publication was financed by the Science Development Fund of the Warsaw University of Life Sciences – SGGW. | |
| dc.identifier.citation | Environ Int. 2025 Feb:196:109281. doi: 10.1016/j.envint.2025.109281. Epub 2025 Jan 16 | |
| dc.identifier.doi | 10.1016/j.envint.2025.109281 | |
| dc.identifier.eissn | 1873-6750 | |
| dc.identifier.issn | 0160-4120 | |
| dc.identifier.pmid | 39842165 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/10607 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Elsevier | |
| dc.relation | European Human Biomonitoring Initiative | |
| dc.relation.hasversion | https://www.sciencedirect.com/science/article/pii/S0160412025000327?via%3Dihub#s0065 | |
| dc.relation.ispartof | Environment International | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Untargeted Metabolomics | |
| dc.subject | Human Biomontoring | |
| dc.subject | Environmental Genotoxicity | |
| dc.subject | Occupational Study | |
| dc.subject | Genotoxocidade Ambiental | |
| dc.subject | Biomarkers | |
| dc.title | HBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recycling | eng |
| dc.type | journal article | |
| dcterms.references | https://www.sciencedirect.com/science/article/pii/S0160412025000327?via%3Dihub#da005:~:text=Download%20all%20supplementary%20files%20included%20with%20this%20article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | European Human Biomonitoring Initiative | |
| oaire.awardURI | info:eu-repo/grantAgreement/EC/H2020/733032/EU | |
| oaire.citation.startPage | 109281 | |
| oaire.citation.title | Environment International | |
| oaire.citation.volume | 196 | |
| oaire.fundingStream | H2020 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| project.funder.identifier | http://doi.org/10.13039/501100008530 | |
| project.funder.name | European Commission | |
| relation.isProjectOfPublication | 6815dc2d-ef7e-4535-8dd3-5193c8bffba5 | |
| relation.isProjectOfPublication.latestForDiscovery | 6815dc2d-ef7e-4535-8dd3-5193c8bffba5 |