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Polycyclic aromatic hydrocarbon (PAH) exposure among European adults: Evidence from the HBM4EU aligned studies

2025-03-16Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorKarakoltzidis, Achilleas
dc.contributor.authorPapaioannou, Nafsika
dc.contributor.authorGabriel, Catherine
dc.contributor.authorChatzimpaloglou, Anthoula
dc.contributor.authorAndersson, Anna-Maria
dc.contributor.authorJuul, Anders
dc.contributor.authorHalldorsson, Thorhallur I.
dc.contributor.authorOlafsdottir, Kristin
dc.contributor.authorKlanova, Jana
dc.contributor.authorPiler, Pavel
dc.contributor.authorJanasik, Beata
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorJanev-Holcer, Natasa
dc.contributor.authorNamorado, Sónia
dc.contributor.authorRambaud, Loïc
dc.contributor.authorRiou, Margaux
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorImboden, Medea
dc.contributor.authorNieuwenhuyse, An Van
dc.contributor.authorAppenzeller, Brice M.R.
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorWeber, Till
dc.contributor.authorStewart, Lorraine
dc.contributor.authorSepai, Ovnair
dc.contributor.authorEsteban-López, Marta
dc.contributor.authorCastaño, Argelia
dc.contributor.authorGilles, Liese
dc.contributor.authorGovarts, Eva
dc.contributor.authorRodriguez Martin, Laura
dc.contributor.authorSchoeters, Greet
dc.contributor.authorKarakitsios, Spyros
dc.contributor.authorSarigiannis, Dimosthenis Α.
dc.contributor.authorNamorado, Sónia
dc.date.accessioned2026-01-22T12:29:18Z
dc.date.available2026-01-22T12:29:18Z
dc.date.issued2025-03-16
dc.description.abstractPolycyclic aromatic hydrocarbons (PAHs) are persistent environmental pollutants with well-documented associations to adverse health effects, posing significant public health challenges across Europe. Human exposure to 13 urinary PAH metabolites was assessed in a harmonized cohort of European adults aged 20-39, representing diverse geographic regions across Europe: North (Iceland and Denmark), East (Poland and the Czech Republic), South (Croatia and Portugal), and West (France, Germany, Switzerland, and Luxembourg). This study aimed to achieve a unified understanding of PAH exposure by employing stringent participant selection criteria and harmonizing biomarker analyses by utilizing high-quality analytical protocols across multiple laboratories in Europe. Key findings revealed consistently elevated metabolite levels in smokers compared to non-smokers, with naphthalene metabolites dominating the profiles over phenanthrene and fluorene derivatives. Country-specific analyses highlighted Poland as having the highest naphthalene metabolite concentrations, while Luxembourg exhibited elevated pyrene metabolite levels. Urbanization influenced exposure, with slightly higher metabolite concentrations in town populations compared to rural areas. While sex-based stratification revealed no marked differences, gender emerged as a significant covariate in regression models, with women generally displaying higher exposure to naphthalene metabolites. Educational level further stratified exposure, with lower education correlating with increased PAH levels. Multivariate linear regression identified key exposure factors, including sampling season (i.e., summer, winter, autumn, and spring), dietary habits e.g., smoked foods, and proximity to smoke-prone environments. This dataset provides a significant baseline for evaluating the European Commission's Chemicals Strategy for Sustainability (CSS) and underscores the utility of harmonized human biomonitoring studies in informing targeted public health interventions.eng
dc.description.sponsorshipFunding for HBM4EU from the European Union’s Horizon 2020 research and innovation program under grant agreement 733032 and the national governments of the participating countries.
dc.identifier.citationEnviron Int. 2025 Apr:198:109383. doi: 10.1016/j.envint.2025.109383. Epub 2025 Mar 16
dc.identifier.doi10.1016/j.envint.2025.109383
dc.identifier.eissn1873-6750
dc.identifier.issn0160-4120
dc.identifier.pmid40132439
dc.identifier.urihttp://hdl.handle.net/10400.18/10739
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0160412025001345?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectExposure Assessment
dc.subjectHuman Biomonitoring
dc.subjectExposure Determinants
dc.subjectPAHs
dc.subjectDeterminantes da Saúde e da Doença
dc.subjectBiomonitorização Humana
dc.subjectHidrocarbonetos Aromáticos Policíclicos
dc.subjectDeterminantes da Exposição
dc.subjectAvaliação da Exposição
dc.titlePolycyclic aromatic hydrocarbon (PAH) exposure among European adults: Evidence from the HBM4EU aligned studieseng
dc.typejournal article
dcterms.referenceshttps://www.sciencedirect.com/science/article/pii/S0160412025001345?via%3Dihub
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.startPage109383
oaire.citation.titleEnvironment International
oaire.citation.volume198
oaire.fundingStreamH2020
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameNamorado
person.givenNameSónia
person.identifier.orcid0000-0002-7500-8811
person.identifier.ridD-7168-2015
person.identifier.scopus-author-id14047182500
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
relation.isAuthorOfPublication4ed6a689-2426-46ea-90e6-1950652a288b
relation.isAuthorOfPublication.latestForDiscovery4ed6a689-2426-46ea-90e6-1950652a288b
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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