Publication
In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol
| dc.contributor.author | Querido, Micaela | |
| dc.contributor.author | Rosário, Fernanda | |
| dc.contributor.author | Bessa, Maria | |
| dc.contributor.author | Mendes, Francisca | |
| dc.contributor.author | Teixeira, José | |
| dc.contributor.author | Teixeira, João | |
| dc.contributor.author | Pereira, Cristiana | |
| dc.date.accessioned | 2023-03-21T15:42:59Z | |
| dc.date.available | 2023-03-21T15:42:59Z | |
| dc.date.issued | 2022-01-27 | |
| dc.description | This article belongs to the Section Toxicology. | pt_PT |
| dc.description.abstract | Surfaces with antimicrobial properties are gaining notoriety as an efficient method to avoid surface contamination. Self-disinfecting paints are a promising strategy towards cleaner indoor environments by preventing the colonization of walls with microorganisms. However, its widespread use needs an appropriate toxicological safety evaluation due to the potential for biological disturbance associated to its biocidal activity. In this work, the cyto- and genotoxic assessment of two self-disinfecting paints containing the antimicrobial substances triclosan (TCS) and isoborneol (ISB) is performed. HaCaT and A549 cell lines models were selected for the in vitro assessment. To evaluate the cytotoxicity, tests by direct contact and on extracts obtained from leaching were performed following ISO 10993, whereas the genotoxicity was assessed by comet assay and cytokinesis-block micronucleus (CBMN) assay. The results showed low levels of cyto- and genotoxicity under the models and conditions tested, indicating that these substances have commercial potential. | pt_PT |
| dc.description.sponsorship | This research was funded by Programa Operacional Competitividade e Internacionalização— COMPETE2020/FEDER, towards the project B-Safecoat (POCI-01-0247-FEDER-017875), and by FCT (Fundação para a Ciência e Tecnologia) through the PhD grants awarded to M.M.Q. (SFRH/BD/130203/2017) and M.J.B (SFRH/BD/120646/2016). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Toxics. 2022 Jan 27;10(2):58. doi: 10.3390/toxics10020058. | pt_PT |
| dc.identifier.doi | 10.3390/toxics10020058 | pt_PT |
| dc.identifier.issn | 2305-6304 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/8593 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | DesinFAST-Self-Disinfecting Paint for Infection Control in Public Spaces | |
| dc.relation | Assessing the toxicity of airborne nanoceramics in vitro and in vivo- contribution to the safe production and use of nanomaterials in the ceramic industry | |
| dc.relation.publisherversion | https://www.mdpi.com/2305-6304/10/2/58 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Antibacterial | pt_PT |
| dc.subject | Cytotoxicity | pt_PT |
| dc.subject | Genotoxicity | pt_PT |
| dc.subject | Isoborneol | pt_PT |
| dc.subject | Paint | pt_PT |
| dc.subject | Triclosan | pt_PT |
| dc.subject | Genotoxicidade Ambiental | pt_PT |
| dc.title | In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | DesinFAST-Self-Disinfecting Paint for Infection Control in Public Spaces | |
| oaire.awardTitle | Assessing the toxicity of airborne nanoceramics in vitro and in vivo- contribution to the safe production and use of nanomaterials in the ceramic industry | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F130203%2F2017/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F120646%2F2016/PT | |
| oaire.citation.issue | 2 | pt_PT |
| oaire.citation.startPage | 58 | pt_PT |
| oaire.citation.title | Toxics | pt_PT |
| oaire.citation.volume | 10 | pt_PT |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | Acesso de acordo com política editorial da revista. | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | 8c1a52a8-15d9-4bd0-b94c-8320cbef5a1e | |
| relation.isProjectOfPublication | 28045083-dc0a-40cf-9538-c1ef7ff6784e | |
| relation.isProjectOfPublication.latestForDiscovery | 8c1a52a8-15d9-4bd0-b94c-8320cbef5a1e |