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Impact of wildfire emissions exposure on the associations between levels of lung injury, lipid peroxidation, DNA oxidation, and exposure biomarkers

2025-07-04Artigo científico Acesso aberto
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dc.contributor.authorBarros, Bela
dc.contributor.authorPaiva, Ana Margarida
dc.contributor.authorAzevedo, Rui
dc.contributor.authorAlves, Sara
dc.contributor.authorEsteves, Filipa
dc.contributor.authorFernandes, Adília
dc.contributor.authorVaz, Josiana
dc.contributor.authorAlves, Maria José
dc.contributor.authorSlezakova, Klara
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCosta, Solange
dc.contributor.authorAlmeida, Agostinho
dc.contributor.authorOliveira, Marta
dc.contributor.authorMorais, Simone
dc.date.accessioned2026-02-20T15:22:35Z
dc.date.available2026-02-20T15:22:35Z
dc.date.issued2025-07-04
dc.description.abstractFirefighters face increased risks of developing cardio-respiratory diseases and cancer. This study aimed, for the first time, to simultaneously characterize several biomarkers of effect (lung injury by Clara cell 16 -CC16, lipid peroxidation by 8-isoprostane-8-iso, and DNA oxidation by 8-hydroxy-2-deoxyguanosine-8-OHdG) and exposure (polycyclic aromatic hydrocarbons metabolites - 6 OHPAHs and 17 metal(loid)s) in (pre- and post-exposure) paired urine samples of wildland firefighters, while exploring their inter-/intra-associations and accounting for tobacco consumption. Wildfire combat influenced the levels of CC16 (+39 %), 8-iso (+33 %), 8-OHdG (-13 to +19 %), individual and sum of OHPAHs (+75-211 %), and metal(loid)s (up to 43 %, p > 0.05: lithium, zinc, antimony, and lead); post-exposure increments were more evident among non-smokers. Post-exposure (individual and sum) OHPAHs and some metal(loid)s (copper, cadmium, barium, antimony, copper, lead, zinc, selenium, and rubidium) were positively associated with CC16, 8-iso and/or 8-OHdG (0.609 < r < 0.838; 0.001 < p < 0.047). Spearman's correlations and principal component analysis highlighted CC16 as the best discriminant effect biomarker of wildland firefighting, correlating positively with individual and sum of OHPAHs, cadmium, barium and copper (0.647 < r < 0.764; 0.006 < p < 0.031). Cumulative exposure to wildfires and tobacco contributed to positive correlations (0.587 < r < 0.715; 0.009 < p < 0.045) between lipid peroxidation and arsenic, antimony, lead, and copper, and between DNA oxidation and lead. Smoking firefighters presented higher OHPAHs baseline concentrations (2- to 14-fold), and lung injury and DNA oxidation induced by cadmium, copper, strontium, cesium, barium and thallium (0.661 < r < 0.709; 0.022 < p < 0.038). Given firefighter's carcinogenic risks, performing similar studies in larger groups is crucial to enhance risk assessment by establishing a well-defined panel of effect and exposure biomarkers.eng
dc.description.abstractHighlights: - Wildfire combat contributed to lung injury, DNA oxidation, lipid peroxidation. - Urinary Clara cell 16 arose as a key effect biomarker of wildland firefighting. - Smokers exposed to wildfires showed increased metal(loid)s-induced oxidative stress. - Individual and sum of OHPAHs correlated with all three effect biomarkers. - Wildfire exposure and health impacts were more evident among non-smokers.eng
dc.description.sponsorshipThis work was financed through project BioFirEx: PCIF/SSO/0017/2018 (http://doi.org/10.54499/PCIF/SSO/0017/2018) by the Fundação para a Ciência e a Tecnologia, Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES), through national funds.
dc.identifier.citationSci Total Environ. 2025 Sep 1:993:180012. doi: 10.1016/j.scitotenv.2025.180012. Epub 2025 Jul 4
dc.identifier.doi10.1016/j.scitotenv.2025.180012
dc.identifier.issn0048-9697
dc.identifier.pmid40617105
dc.identifier.urihttp://hdl.handle.net/10400.18/10970
dc.language.isoen
dc.peerreviewedyes
dc.publisherElsevier
dc.relationA panel of (bio)markers for the surveillance of firefighter's health and safety.
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0048969725016523?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBiomarkers of effect
dc.subjectFirefighters
dc.subjectHydroxylated polycyclic aromatic hydrocarbons
dc.subjectMetals and metalloids
dc.subjectOccupational health
dc.subjectAr e Saúde Ocupacional
dc.subjectToxicologia
dc.titleImpact of wildfire emissions exposure on the associations between levels of lung injury, lipid peroxidation, DNA oxidation, and exposure biomarkerseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPCIF/SSO/0017/2018
oaire.awardTitleA panel of (bio)markers for the surveillance of firefighter's health and safety.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de Investigação Científica e Desenvolvimento Tecnológico no Âmbito da Prevenção e Combate a Incêndios Florestais - 2018/PCIF%2FSSO%2F0017%2F2018/PT
oaire.citation.startPage180012
oaire.citation.titleScience of the Total Environment
oaire.citation.volume993
oaire.fundingStreamConcurso de Projetos de Investigação Científica e Desenvolvimento Tecnológico no Âmbito da Prevenção e Combate a Incêndios Florestais - 2018
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublicatione03b6804-4e26-4c3d-9cc7-8d614b5d4333
relation.isProjectOfPublication.latestForDiscoverye03b6804-4e26-4c3d-9cc7-8d614b5d4333

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