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Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge

2023-02-24Artigo científico Acesso aberto
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dc.contributor.authorRodríguez-Carrillo, Andrea
dc.contributor.authorMustieles, Vicente
dc.contributor.authorSalamanca-Fernández, Elena
dc.contributor.authorOlivas-Martínez, Alicia
dc.contributor.authorSuárez, Beatriz
dc.contributor.authorBajard, Lola
dc.contributor.authorBaken, Kirsten
dc.contributor.authorBlaha, Ludek
dc.contributor.authorBonefeld-Jørgensen, Eva Cecilie
dc.contributor.authorCouderq, Stephan
dc.contributor.authorD'Cruz, Shereen Cynthia
dc.contributor.authorFini, Jean-Baptiste
dc.contributor.authorGovarts, Eva
dc.contributor.authorGundacker, Claudia
dc.contributor.authorHernández, Antonio F.
dc.contributor.authorLacasaña, Marina
dc.contributor.authorLaguzzi, Federica
dc.contributor.authorLinderman, Birgitte
dc.contributor.authorLong, Manhai
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorNeophytou, Christiana
dc.contributor.authorOberemn, Axel
dc.contributor.authorRemy, Sylvie
dc.contributor.authorRosenmai, Anna Kjerstine
dc.contributor.authorSaber, Anne Thoustrup
dc.contributor.authorSchoeters, Greet
dc.contributor.authorSilva, Maria João
dc.contributor.authorSmagulova, Fatima
dc.contributor.authorUhl, Maria
dc.contributor.authorVinggaard, Anne Marie
dc.contributor.authorVogel, Ulla
dc.contributor.authorWielsøe, Maria
dc.contributor.authorOlea, Nicolás
dc.contributor.authorFernández, Mariana F.
dc.date.accessioned2023-10-06T13:24:59Z
dc.date.available2023-10-06T13:24:59Z
dc.date.issued2023-02-24
dc.descriptionReviewpt_PT
dc.description.abstractHuman biomonitoring (HBM) studies have highlighted widespread daily exposure to environmental chemicals. Some of these are suspected to contribute to adverse health outcomes such as reproductive, neurological, and metabolic disorders, among other developmental and chronic impairments. One of the objectives of the H2020 European Human Biomonitoring Initiative (HBM4EU) was the development of informative effect biomarkers for application in a more systematic and harmonized way in large-scale European HBM studies. The inclusion of effect biomarkers would complement exposure data with mechanistically-based information on early and late adverse effects. For this purpose, a stepwise strategy was developed to identify and implement a panel of validated effect biomarkers in European HBM studies. This work offers an overview of the complete procedure followed, from comprehensive literature search strategies, selection of criteria for effect biomarkers and their classification and prioritization, based on toxicological data and adverse outcomes, to pilot studies for their analytical, physiological, and epidemiological validation. We present the example of one study that demonstrated the mediating role of the effect biomarker status of brain-derived neurotrophic factor BDNF in the longitudinal association between infant bisphenol A (BPA) exposure and behavioral function in adolescence. A panel of effect biomarkers has been implemented in the HBM4EU Aligned Studies as main outcomes, including traditional oxidative stress, reproductive, and thyroid hormone biomarkers. Novel biomarkers of effect, such as DNA methylation status of BDNF and kisspeptin (KISS) genes were also evaluated as molecular markers of neurological and reproductive health, respectively. A panel of effect biomarkers has also been applied in HBM4EU occupational studies, such as micronucleus analysis in lymphocytes and reticulocytes, whole blood comet assay, and malondialdehyde, 8-oxo-2′-deoxyguanosine and untargeted metabolomic profile in urine, to investigate, for example, biological changes in response to hexavalent chromium Cr(VI) exposure. The use of effect biomarkers in HBM4EU has demonstrated their ability to detect early biological effects of chemical exposure and to identify subgroups that are at higher risk. The roadmap developed in HBM4EU confirms the utility of effect biomarkers, and support one of the main objectives of HBM research, which is to link exposure biomarkers to mechanistically validated effect and susceptibility biomarkers in order to better understand the public health implications of human exposure to environmental chemicals.pt_PT
dc.description.sponsorshipSupported by the European Union's Horizon 2020 research and innovation program projects HBM4EU [grant number 733032]pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Hyg Environ Health. 2023 Apr:249:114140. doi: 10.1016/j.ijheh.2023.114140. Epub 2023 Feb 24. Reviewpt_PT
dc.identifier.doi10.1016/j.ijheh.2023.114140pt_PT
dc.identifier.issn1438-4639/
dc.identifier.urihttp://hdl.handle.net/10400.18/8668
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://doi.org/10.1016/j.ijheh.2023.114140pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectEffect Biomarkerspt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleImplementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledgept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.startPage114140pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume249pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com a página web da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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