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Contribute of the MYCOMIX project and future perspectives for Human Biomonitoring and health risk assessment in Portugal

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dc.contributor.authorMartins, Carla
dc.contributor.authorAssunĆ§Ć£o, Ricardo
dc.contributor.authorSilva, M.J.
dc.contributor.authorLouro, H.
dc.contributor.authorPinhĆ£o, M.
dc.contributor.authorNunes, Baltazar
dc.contributor.authorVasco, Elsa
dc.contributor.authorAlvito, Paula
dc.date.accessioned2016-08-09T14:11:14Z
dc.date.available2016-08-09T14:11:14Z
dc.date.issued2016-04
dc.description.abstractThere is a growing concern within public health about mycotoxin involvement in human diseases, namely those related to children. The MycoMix project (2012-2015), funded by the Portuguese Foundation for Science and Technology, gathered a multidisciplinary team aiming at answering several questions: 1) Are Portuguese children exposed daily to one or several mycotoxins through food? 2) Can this co-exposure affect childrenĀ“s health? and 3) Are there interaction effect between mycotoxins? Mycomix results revealed that Portuguese children (< 3 years old, n=103) are exposed to multiple mycotoxins through food consumption. Cumulative risk assessment results revealed a potential health concern for the high percentiles of intake, specially for aflatoxins which are carcinogenic compounds. This fact assumes particular importance considering the interactive effects found in in vitro bioassays. These results highlight the need for a more accurate approach to assess the human exposure to mycotoxins6. Within the Mycomix project the assessment of mycotoxin exposure was based on calculations combining mycotoxin data in food with population data on food consumption. This approach does not consider some aspects as the inter-individual metabolism variation, the exposure through sources other than food and the heterogeneous distribution of mycotoxins in food. Exposure assessment of mycotoxins in Portuguese population through biomarkers is still missing and further studies are urgent to be developed. The European Human Biomonitoring Initiative (EHBMI), a proposal within the European Joint Programme, aims to advance the understanding of the extent of exposure to environmental chemicals across Europe and the impact on human health, by gathering national expertise in human biomonitoring domain. At national level Mycomix project uncovered the potential health risk of exposure of Portuguese children to multiple mycotoxins. The risk assessment expertise acquired within Mycomix, namely in analysis and toxicology of chemical mixtures, will be brought together as a contribute to EHBMI objectives.pt_PT
dc.description.sponsorshipThis research was performed under the MYCOMIX project ā€œExploring the toxic effects of mixtures of mycotoxins in infant food and potential health impactā€ (PTDC/DTPFTO/0417/2012), through CESAM: UID/AMB/50017/2013 and ToxOmics Portugal, all funded by the FundaĆ§Ć£o para a CiĆŖncia e Tecnologia (FCT), Portugal.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/3907
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSeguranƧa Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliaĆ§Ć£o de Riscopt_PT
dc.subjectSaĆŗde Humanapt_PT
dc.subjectGenotoxicidade Ambiental
dc.subjectDeterminantes da SaĆŗde e da DoenƧa
dc.titleContribute of the MYCOMIX project and future perspectives for Human Biomonitoring and health risk assessment in Portugalpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0417%2F2012/PT
oaire.citation.conferencePlaceBerlim, Alemanhapt_PT
oaire.citation.title2nd International Conference on Human Biomonitoring: Science and policy for a healthy future, 17-19 abril 2016pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundaĆ§Ć£o para a CiĆŖncia e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication7dee8a4a-7112-45ce-a8cb-8c552d7ae061
relation.isProjectOfPublication.latestForDiscovery7dee8a4a-7112-45ce-a8cb-8c552d7ae061

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