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Recommendations for estimating and reporting vaccine effectiveness by time since vaccination: a COVID-19 case study

2025-11-17Artigo científico Acesso restrito
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorKissling, Esther
dc.contributor.authorNunes, Baltazar
dc.contributor.authorHooiveld, Mariëtte
dc.contributor.authorMartínez-Baz, Iván
dc.contributor.authorMonge, Susana
dc.contributor.authorRobertson, Chris
dc.contributor.authorKnolm, Mirjam
dc.contributor.authorSève, Noémie
dc.contributor.authorMlinarić, Ivan
dc.contributor.authorDomegan, Lisa
dc.contributor.authorMachado, Ausenda
dc.contributor.authorWhitaker, Heather
dc.contributor.authorLazar, Mihaela
dc.contributor.authorMeijer, Adam
dc.contributor.authorEnkirch, Theresa
dc.contributor.authorCasado, Itziar
dc.contributor.authorPérez-Gimeno, Gloria
dc.contributor.authorWilliam, Naoma
dc.contributor.authorEnouf, Vincent
dc.contributor.authorKurečić Filipović, Sanja
dc.contributor.authorMcKenna, Adele
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorde Lusignan, Simon
dc.contributor.authorTimnea, Olivia-Carmen
dc.contributor.authorLatorre-Margalef, Neus
dc.contributor.authorCastilla, Jesús
dc.contributor.authorPozo, Francisco
dc.contributor.authorHamilton, Mark
dc.contributor.authorMasse, Shirley
dc.contributor.authorIlić, Maja
dc.contributor.authorBasile, Luca
dc.contributor.authorO’Donnell, Joan
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorRiess, Maximilian
dc.contributor.authorPopescu, Rodica-Manuela
dc.contributor.authorM C Rose, Angela
dc.contributor.authorAndrews, Nick
dc.contributor.authorBacci, Sabrina
dc.contributor.authorPastore Celentano, Lucia
dc.contributor.authorValenciano, Marta
dc.contributor.authorMoren, Alain
dc.contributor.authorBeutels, Philippe
dc.contributor.authorHens, Niel
dc.contributor.authorI-MOVE-COVID-19 and ECDC primary care study teams
dc.date.accessioned2026-01-29T13:01:29Z
dc.date.available2026-01-29T13:01:29Z
dc.date.issued2025-11-17
dc.description.abstractEstimating COVID-19 vaccine effectiveness (VE) by time since vaccination (TSV) is essential for understanding how protection may change over time and enables meaningful comparisons across studies. This is important for accurate comparisons of VE against different SARS-CoV-2 variants/sublineages, across age groups, during different periods post vaccination campaign, or by vaccine type/brand. We provide recommendations for case–control VE studies on estimating and reporting VE analyses by TSV, with the aim of improving quality of these estimates. Our recommendations cover study design and pre-analysis considerations, descriptive analyses, choice of categories of TSV, categorical and continuous modelling approaches, and best practices for reporting VE by TSV. Using a real-life case–control study, we apply these recommendations, and include accompanying statistical scripts in R and Stata. These recommendations will serve as a practical resource for researchers conducting VE analyses by TSV. We encourage ongoing refinement of them through input from other study groups.eng
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003673. This project received funding from the European Centre for Disease Prevention and Control (ECDC) under the contract ECD.11486.
dc.identifier.citationAm J Epidemiol. 2025 Nov 17:kwaf254. doi: 10.1093/aje/kwaf254. Online ahead of print
dc.identifier.doi10.1093/aje/kwaf254
dc.identifier.eissn1476-6256
dc.identifier.issn0002-9262
dc.identifier.urihttp://hdl.handle.net/10400.18/10787
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.relationMultidisciplinary European network for research, prevention and control of the COVID-19 Pandemic
dc.relation.hasversionhttps://academic.oup.com/aje/advance-article/doi/10.1093/aje/kwaf254/8325014
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCase–Control Study
dc.subjectCovid-19
dc.subjectEpidemiological Methods
dc.subjectTime Since Vaccination
dc.subjectVaccine Effectiveness
dc.subjectEstados de saúde
dc.subjectInfecções Respiratórias
dc.titleRecommendations for estimating and reporting vaccine effectiveness by time since vaccination: a COVID-19 case studyeng
dc.typejournal article
dcterms.referenceshttps://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/aje/PAP/10.1093_aje_kwaf254/1/web_material_kwaf254.docx?Expires=1772714919&Signature=j0ce0f~AiFGG-9TbNG8jqkM9ZwmeCsqAQXKy5uob3pnotAK49hJwx5HTOh0JeiWFO3gR0uBMsNVmoyBHJKYkQ1vVpCqdlqIDhSs~YM~rUb-rH76QZHxZoE62GUeVGRBa5u-D3qA1XOmzXvxdHkMWZZ2U-cTE3NBh~uaFSplfDFBvSGnn7DjIYKisdZQ3eXkLAC9exmk2EmQu3rV-Bs5J9erNQIHteilpqzdIBgiVwjNCEhCr9w8cIBoTtcJjIJlZrl44ghTyKNe7X9ZGHoT9uvfD-v9FfQ7sUc0VgYvk3dAwFE4wEbOfbFEcECO0Nw-uXoIuoZfnmt9ohqNe1PNeIA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
dspace.entity.typePublication
oaire.awardTitleMultidisciplinary European network for research, prevention and control of the COVID-19 Pandemic
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/101003673/EU
oaire.citation.startPagekwaf254
oaire.citation.titleAmerican Journal of Epidemiology
oaire.fundingStreamH2020
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
relation.isProjectOfPublication7403e02d-5360-418c-8e37-687c3a1349f8
relation.isProjectOfPublication.latestForDiscovery7403e02d-5360-418c-8e37-687c3a1349f8

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