Repository logo
 
Publication

Evolutionary Insights into IL17A in Lagomorphs

2015-12-15Journal article Open access
Simple item page
dc.contributor.authorNeves, Fabiana
dc.contributor.authorAbrantes, Joana
dc.contributor.authorAlmeida, Tereza
dc.contributor.authorCosta, Paulo P.
dc.contributor.authorEsteves, Pedro J.
dc.date.accessioned2016-02-12T15:16:09Z
dc.date.available2016-02-12T15:16:09Z
dc.date.issued2015-12-15
dc.description.abstractIn leporids, IL17A had been implicated in the host defense against extracellular pathogens, such as Francisella tularensis that infects hares and rabbits and causes the zoonotic disease tularemia. Here, we studied IL17A from five lagomorphs, European rabbit, pygmy rabbit, brush rabbit, European brown hare, and American pika. We observed that this protein is highly conserved between these species, with a similarity of 97-99% in leporids and ~88% between leporids and American pika. The exon/intron structure, N-glycosylation sites, and cysteine residues are conserved between lagomorphs. However, at codon 88, one of the interaction sites between IL17A and its receptor IL17RA, there is an Arg>Pro mutation that only occurs in European rabbit and European brown hare. This could induce critical alterations in the IL17A structure and conformation and consequently modify its function. The differences observed between leporids and humans or rodents might also represent important alterations in protein structure and function. In addition, as for other interleukins, IL17A sequences of human and European rabbit are more closely related than the sequences of human and mouse or European rabbit and mouse. This study gives further support to the hypothesis that European rabbit might be a more suitable animal model for studies on human IL17.pt_PT
dc.description.sponsorshipFCT and North Portugal Regional Operational Programme 2007/2013 (ON.2) grants supported this work.pt_PT
dc.identifier.citationMediators Inflamm. 2015;2015:367670. doi: 10.1155/2015/367670. Epub 2015 Dec 15pt_PT
dc.identifier.doi10.1155/2015/367670pt_PT
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/10400.18/3280
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relation.publisherversionwww.hindawi.com/journals/mi/2015/367670/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCell and molecular biologypt_PT
dc.subjectGeneticspt_PT
dc.subjectImmunologypt_PT
dc.subjectRabbitpt_PT
dc.subjectLagomorphapt_PT
dc.subjectIL17Apt_PT
dc.subjectDeterminantes da Saúde e da Doença
dc.titleEvolutionary Insights into IL17A in Lagomorphspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMediators of Inflammationpt_PT
oaire.citation.volume2015pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Neves 2015 - Evolutionary Insights into IL17A in Lagomorphs.pdf
Size:
1.56 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DGH - Artigos em revistas internacionais