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From trihalomethanes chronic daily intake through multiple exposure routes to cancer and non-cancer health risk assessment: Evidence from public Portuguese indoor swimming pools facilities using a probabilistic approach

2022-04-20Journal article Restricted access
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dc.contributor.authorCosta, Carla
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorSequeira, Diana
dc.contributor.authorEsteves, Filipa
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorLaffon, Blanca
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorMadureira, Joana
dc.date.accessioned2023-01-11T11:56:07Z
dc.date.available2023-01-11T11:56:07Z
dc.date.issued2022-04-20
dc.description.abstractThis study aimed to estimate chronic daily intake (CDI) and to predict the attributable lifetime cancer risk (LCR) and hazard index (HI) from concurrent exposure to four trihalomethanes (THMs; chloroform, bromodichloromethane, dibromochloromethane and bromoform), via multiple exposure routes (oral ingestion, dermal contact and inhalation), among 238 non-competitive attendees of 10 Portuguese public indoor swimming pools (SPs), using a probabilistic approach based on Monte Carlo simulations. Exposure parameters of study participants were collected via questionnaires and THMs levels in SPs water were determined according the respective normative standards. The CDI for total THMs calculated for male and female participants considering all routes was 7.52 and 8.97 mg/kg/day, respectively. SP attendees presented higher CDI through inhalation than via the other two exposure routes, and chloroform was the compound contributing the most to total THMs CDI. The risk analysis indicated that the total LCR and HI from the targeted THMs were higher than the negligible risk levels (1 × 10-6 and 1, respectively) in the scenarios examined (central tendency exposure and reasonable maximum exposure), and the health risk for females was slightly higher than for males. This study suggests that there are possible adverse health risks, thus, to protect pool attendees, adequate mitigation measures, and comprehensive regulatory guidelines on individual THMs concentrations are needed.pt_PT
dc.description.abstractHighlights: Chloroform was the main THM; inhalation route was found to be the most relevant; The carcinogenic risk exceeds U.S. EPA negligible level; The non-carcinogenic risk is several orders greater than the recommended value; Females are more susceptible to cancer and non-cancer risk from total THMs exposure.pt_PT
dc.description.sponsorshipThis work was supported by the Project NORTE-01-0145-FEDER 000010, Health, Comfort and Energy in the Built Environment (HEBE), co-financed by Programa Operacional Regional do Norte (NORTE2020), through the European Regional Development Fund and by the Foundation for Science and Technology – FCT (Portuguese Ministry of Science, Technology and Higher Education) under the project UIDB/04750/2020. Joana Madureira and Carla Costa are supported by FCT (SFRH/BPD/115112/2016 and SFRH/BPD/96196/2013 grants, respectively). Ri cardo Assunção was supported by FCT Individual CEEC 2018 Assistant Researcher Grant CEECIND/01570/2018. The authors are also grateful for the support from Xunta de Galicia [ED431B 2019/02], Ministerio de Educación, Cultura y Deporte [BEAGAL18/00142 to V.V.], Programa IACOBUS Estancias de Investigación 2021; and FCT/MCTES for the financial support to CESAM (UIDP/50017/2020+UIDB/50017/2020) through national funds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Total Environ . 2022 Apr 20;818:151790. doi: 10.1016/j.scitotenv.2021.151790. Epub 2021 Nov 19pt_PT
dc.identifier.doi10.1016/j.scitotenv.2021.151790pt_PT
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10400.18/8426
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
dc.relationImpact of transplacental exposure to tobacco smoke in the DNA of newborn. Evaluation of genetic damage and epigenetic changes. Evolution throughout childhood.
dc.relationNot Available
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://linkinghub.elsevier.com/retrieve/pii/S0048-9697(21)06866-2pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectChloroformpt_PT
dc.subjectEnvironmental Healthpt_PT
dc.subjectHuman Exposurept_PT
dc.subjectMonitoringpt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectTrihalomethanespt_PT
dc.subjectSwimming Poolspt_PT
dc.subjectAvaliação do Riscopt_PT
dc.subjectPortugalpt_PT
dc.subjectÁgua e Solopt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleFrom trihalomethanes chronic daily intake through multiple exposure routes to cancer and non-cancer health risk assessment: Evidence from public Portuguese indoor swimming pools facilities using a probabilistic approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
oaire.awardTitleImpact of transplacental exposure to tobacco smoke in the DNA of newborn. Evaluation of genetic damage and epigenetic changes. Evolution throughout childhood.
oaire.awardTitleNot Available
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F115112%2F2016/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F01570%2F2018%2FCP1559%2FCT0013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.startPage151790pt_PT
oaire.citation.titleScience of the Total Environmentpt_PT
oaire.citation.volume818pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
oaire.fundingStream6817 - DCRRNI ID
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rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
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