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The need for early-stage safety assessment in the development of nanomaterials – the role of nanotoxicology

2020-12-07Conference object Restricted access
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dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.date.accessioned2021-03-13T11:05:18Z
dc.date.available2021-03-13T11:05:18Z
dc.date.issued2020-12-07
dc.description.abstractThe exponential growth of technology based on nanomaterials(NMs), due to their perspectives and application in key sectors such as agriculture, food industry, medicine, energy, environment, and electronics, has led to their increased use. Many products, already available, have NMs, such as silver or titanium dioxide nanomaterials and others are being developed, such as nanocelluloses and nanoformulations of pesticides. However, the NMs’ specific physicochemical properties that confer them beneficial unique characteristics can also elicit nano-bio interactions leading to toxic potential and concerns for public health. Furthermore, their properties can be affected by the surrounding matrix, leading to secondary features potentially more relevant then primary characteristics for determining the toxicological outcome. Processes like intake or digestion may modify the NMs characteristics leading to unexpected toxicity in human cells. Due to these uncertainties, the investigation of the genotoxic properties of NMs that may imply cancer onset has been mostly inconclusive. Therefore, to contribute for the safety assessment of NMs, it is important to try to ascertain the NM characteristics, primary or secondary, that determine the adverse effects, allowing the synthesis of innovative NMs devoid of toxicity. Here, the nanotoxicology approaches to the hazard assessment of titanium dioxide nanomaterials and nanocelluloses is presented. It is precluded that incorporating adequate nanosafety assessment early in the development of new NMs, will lead to a “safe-by-design” approach that will enable safety to keep pace with innovation.pt_PT
dc.description.sponsorshipThis work was funded by FCT/MCTES through national funds (PIDDAC), PTDC/SAUPUB/29481/2017 and PTDC/SAUPUB/32587/2017, and co-funded by UIDP/00009/2020 (Centre for Toxicogenomics and Human Health – ToxOmics, FCT).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7435
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
dc.subjectNanomaterialspt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectTitanium Dioxide Nanomaterialspt_PT
dc.subjectNanocellulosept_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleThe need for early-stage safety assessment in the development of nanomaterials – the role of nanotoxicologypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F32587%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F00009%2F2013/PT
oaire.citation.conferencePlace(online)pt_PT
oaire.citation.title6th NanoBoston Conference (Virtual), 7-9 December 2020pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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