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Canine lymphoma and vector‐borne diseases: Molecular and serological evaluation of a possible complicity

2020-03Journal article Restricted access
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dc.contributor.authorHenriques, Joaquim
dc.contributor.authorFelisberto, Ricardo
dc.contributor.authorAlmeida, Bruno
dc.contributor.authorRamos, Joana
dc.contributor.authorConstantino‐Casas, Fernando
dc.contributor.authorDobson, Jane
dc.contributor.authorMatos, Raquel
dc.contributor.authorSantos, Ana
dc.contributor.authorSousa, Rita
dc.contributor.authorAlves, Margarida
dc.date.accessioned2021-04-05T16:11:32Z
dc.date.available2021-04-05T16:11:32Z
dc.date.issued2020-03
dc.description.abstractLymphoma is the most common haematological malignancy in dogs and its aetiology is largely unknown. The presence of canine vector-borne agents (CVBD) in lymphoma tissues has been described and its causative effects questioned. We intended to evaluate the presence and extent of Leishmania infantum, Ehrlichia canis, Anaplasma phagocytophilum and Bartonella henselae infection in dogs with lymphoma. Sixty-one dogs, living in the Lisbon metropolitan area, with a diagnosis of lymphoma were enrolled. Immunofluorescence assays were used to detect serum IgG's. The presence of DNA from CVBD agents in tumour tissue was assessed by PCR. All dogs tested negative for B. henselae, A. phagocytophilum and E. canis by both serology and PCR. Regarding L. infantum, 8.2% (n = 5) of the dogs had a positive serologic result. L. infantum DNA was detected in two samples of diffuse large B-cell lymphoma (DLBCL). These results show an increased, but not significant, seropositivity (8.2% vs 7.9%) and molecular detection (3.3% vs 1.2%) for L. infantum in dogs with lymphoma, when compared to the reported canine population in the same geographical area. We could not identify an association between lymphoma and E. canis, A. phagocytophilum, B. henselae or Leishmania infantum infection in the studied population. Nevertheless, further studies, following dogs trough their CVBD disease evolution, are worthwhile and may help clarify a possible role of CVBD agents in lymphomagenesis.pt_PT
dc.description.sponsorshipBayer Animal Health- Portugalpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVet Comp Oncol. 2021 Mar;19(1):183-190. doi: 10.1111/vco.12658. Epub 2020 Nov 3.pt_PT
dc.identifier.doi10.1111/vco.12658pt_PT
dc.identifier.issn1476-5810
dc.identifier.urihttp://hdl.handle.net/10400.18/7638
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/vco.12658pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectLeishmaniapt_PT
dc.subjectDiffuse Large B-cellpt_PT
dc.subjectDog;pt_PT
dc.subjectInfectious Diseasespt_PT
dc.subjectLymphomapt_PT
dc.subjectVector-Bornept_PT
dc.subjectInfecções Sistémicas e Zoonosespt_PT
dc.titleCanine lymphoma and vector‐borne diseases: Molecular and serological evaluation of a possible complicitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage190pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage183pt_PT
oaire.citation.titleVeterinary and Comparative Oncologypt_PT
oaire.citation.volume19pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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