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Severe Congenital Heart Defects and Cerebral Palsy

2023-07-18Journal article Open access
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dc.contributor.authorGarne, Ester
dc.contributor.authorGoldsmith, Shona
dc.contributor.authorBarisic, Ingeborg
dc.contributor.authorBraz, Paula
dc.contributor.authorDakovic, Ivana
dc.contributor.authorGibson, Catherine
dc.contributor.authorHansen, Michele
dc.contributor.authorHoei-Hansen, Christina E.
dc.contributor.authorHollung, Sandra Julsen
dc.contributor.authorKlungsøyr, Kari
dc.contributor.authorSmithers-Sheedy, Hayley
dc.contributor.authorVirella, Daniel
dc.contributor.authorBadawi, Nadia
dc.contributor.authorWatson, Linda
dc.contributor.authorMcIntyre, Sarah
dc.date.accessioned2024-01-04T15:40:41Z
dc.date.available2024-01-04T15:40:41Z
dc.date.issued2023-07-18
dc.description.abstractObjective: To report the prevalence of cerebral palsy (CP) in children with severe congenital heart defects (sCHD) and the outcome/severity of the CP. Methods: Population-based, data linkage study between CP and congenital anomaly registers in Europe and Australia. The EUROCAT definition of severe CHD (sCHD) was used. Linked data from 4 regions in Europe and 2 in Australia were included. All children born in the regions from 1991 through 2009 diagnosed with CP and/or sCHD were included. Linkage was completed locally. Deidentified linked data were pooled for analyses. Results:The study sample included 4989 children with CP and 3684 children with sCHD. The total number of livebirths in the population was 1 734 612. The prevalence of CP was 2.9 per 1000 births (95% CI, 2.8-3.0) and the prevalence of sCHD was 2.1 per 1000 births (95% CI, 2.1-2.2). Of children with sCHD, 1.5% (n = 57) had a diagnosis of CP, of which 35 (61%) children had prenatally or perinatally acquired CP (resulting from a brain injury at £28 days of life) and 22 (39%) children had a postneonatal cause (a brain injury between 28 days and 2 years). Children with CP and sCHD more often had unilateral spastic CP and more intellectual impairments than children with CP without congenital anomalies.Conclusions: In high-income countries, the proportion of children with CP is much higher in children with sCHD than in the background population. The severity of disease in children with CP and sCHD is milder compared with children with CP without congenital anomaliespt_PT
dc.description.sponsorshipFunding support received for the overarching Comprehensive CA-CP Study: the Cerebral Palsy Alliance Research Foundation (The Comprehensive CA-CP Study PG1215 and PG2816 and salary support from Cerebral Palsy Alliance Research Foundation (S.G., S.M., H.S.S., N.B.).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Pediatr. 2023 Nov:262:113617. doi: 10.1016/j.jpeds.2023.113617. Epub 2023 Jul 18.pt_PT
dc.identifier.doi10.1016/j.jpeds.2023.113617pt_PT
dc.identifier.issn0022-3476
dc.identifier.urihttp://hdl.handle.net/10400.18/8850
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0022347623004808?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCerebral Palsypt_PT
dc.subjectCongenital Heart Defectpt_PT
dc.subjectCHDpt_PT
dc.subjectBrain Injurypt_PT
dc.subjectIntellectual Impairmentpt_PT
dc.subjectSeveritypt_PT
dc.subjectEUROCATpt_PT
dc.subjectCongenital Anomaliespt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.titleSevere Congenital Heart Defects and Cerebral Palsypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage113617pt_PT
oaire.citation.titleThe Journal of Pediatricspt_PT
oaire.citation.volume262pt_PT
person.familyNameBraz
person.familyNameVirella
person.givenNamePaula
person.givenNameDaniel
person.identifier.ciencia-id261A-49B5-9F1A
person.identifier.orcid0000-0003-3043-2827
person.identifier.orcid0000-0002-5952-5632
person.identifier.scopus-author-id6602564757
rcaap.embargofctAcesso de acordo com a página web do editor da revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa9cd25a1-e308-4175-9338-802416a5a706
relation.isAuthorOfPublication6958a884-7567-4b3d-ab3b-9cde279541f3
relation.isAuthorOfPublication.latestForDiscovery6958a884-7567-4b3d-ab3b-9cde279541f3

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