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Comparative complete scheme and booster effectiveness of COVID‐19 vaccines in preventing SARS‐CoV‐2 infections with SARS‐CoV‐2 Omicron (BA.1) and Delta (B.1.617.2) variants: A case–case study based on electronic health records

2023-03-14Journal article Open access
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dc.contributor.authorKislaya, Irina
dc.contributor.authorPeralta‐Santos, André
dc.contributor.authorBorges, Vítor
dc.contributor.authorVieira, Luís
dc.contributor.authorSousa, Carlos
dc.contributor.authorFerreira, Bibiana
dc.contributor.authorPelerito, Ana
dc.contributor.authorGomes, João Paulo
dc.contributor.authorLeite, Pedro Pinto
dc.contributor.authorNunes, Baltazar
dc.contributor.authoron behalf of PT COVID-19 group
dc.date.accessioned2024-01-23T12:19:37Z
dc.date.available2024-01-23T12:19:37Z
dc.date.issued2023-03-14
dc.description.abstractBackground: Information on vaccine effectiveness in a context of novel variants of concern (VOC) emergence is of key importance to inform public health policies. This study aimed to estimate a measure of comparative vaccine effectiveness between Omicron (BA.1) and Delta (B.1.617.2 and sub-lineages) VOC according to vaccination exposure (primary or booster). Methods: We developed a case-case study using data on RT-PCR SARS-CoV-2-positive cases notified in Portugal during Weeks 49-51, 2021. To obtain measure of comparative vaccine effectiveness, we compared the odds of vaccination in Omicron cases versus Delta using logistic regression adjusted for age group, sex, region, week of diagnosis, and laboratory of origin. Results: Higher odds of vaccination were observed in cases infected by Omicron VOC compared with Delta VOC cases for both complete primary vaccination (odds ratio [OR] = 2.1; 95% confidence interval [CI]: 1.8 to 2.4) and booster dose (OR = 5.2; 95% CI: 3.1 to 8.8), equivalent to reduction of vaccine effectiveness from 44.7% and 92.8%, observed against infection with Delta, to -6.0% (95% CI: 29.2% to 12.7%) and 62.7% (95% CI: 35.7% to 77.9%), observed against infection with Omicron, for complete primary vaccination and booster dose, respectively. Conclusion: Consistent reduction in vaccine-induced protection against infection with Omicron was observed. Complete primary vaccination may not be protective against SARS-CoV-2 infection in regions where Omicron variant is dominant.pt_PT
dc.description.sponsorshipThe acquisition of sequencing equipment and reagents used in this study by the Instituto Nacional de Saúde Doutor Ricardo Jorge was partially funded by the HERA project (grant no. 2021/PHF/23776), supported by the European Commission through the European Centre for Disease Control, and also partially funded by the Genome PT project (grant no. POCI-01-0145-FEDER-022184), supported by COMPETE 2020–Operational Programme for Competitiveness and Internationalisation, Lisboa Portugal Regional Operational Programme, Algarve Portugal Regional Operational, under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund, and by the Portuguese Science and Technology Foundation. The Algarve Biomedical Center Laboratory received public funding through the Project ALG-D2-2021-06 Variants Screen in Southern Portugal–Monitoring Variants of Concern in Southern Portugal and the Portuguese Science and Technology Foundation national support through the Comprehensive Health Research Center (grant no. UIDP/04923/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInfluenza Other Respir Viruses. 2023 Mar 14;17(3):e13121. doi: 10.1111/irv.13121. eCollection 2023 Marpt_PT
dc.identifier.doi10.1111/irv.13121pt_PT
dc.identifier.issn1750-2640
dc.identifier.urihttp://hdl.handle.net/10400.18/8956
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons Ltdpt_PT
dc.relationNational Facility for genome sequencing and analysis
dc.relationComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/irv.13121pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCOVID‐19pt_PT
dc.subjectDelta Variantpt_PT
dc.subjectOmicron Variantpt_PT
dc.subjectSARS‐CoV‐2pt_PT
dc.subjectCase–case Designpt_PT
dc.subjectVaccine Effectivenesspt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.subjectCuidados de Saúdept_PT
dc.subjectPublic Health Policiespt_PT
dc.titleComparative complete scheme and booster effectiveness of COVID‐19 vaccines in preventing SARS‐CoV‐2 infections with SARS‐CoV‐2 Omicron (BA.1) and Delta (B.1.617.2) variants: A case–case study based on electronic health recordspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNational Facility for genome sequencing and analysis
oaire.awardTitleComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9444 - RNIIIE/PINFRA%2F22184%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04923%2F2020/PT
oaire.citation.issue3pt_PT
oaire.citation.startPagee13121pt_PT
oaire.citation.titleInfluenza and Other Respiratory Virusespt_PT
oaire.citation.volume17pt_PT
oaire.fundingStream9444 - RNIIIE
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com a política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication3b8a803c-37e5-4354-93f5-6410d7fb2af7
relation.isProjectOfPublicationfca49be7-f346-4551-94a8-e107ebc974f6
relation.isProjectOfPublication.latestForDiscovery3b8a803c-37e5-4354-93f5-6410d7fb2af7

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