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Challenges in risk assessment of multiple mycotoxins in food

2016-10-11Journal article Open access
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dc.contributor.authorAssunção, Ricardo
dc.contributor.authorSilva, M.J.
dc.contributor.authorAlvito, Paula
dc.date.accessioned2017-02-21T15:47:10Z
dc.date.available2017-02-21T15:47:10Z
dc.date.issued2016-10-11
dc.descriptionReview articlept_PT
dc.description.abstractMost fungi are able to produce several mycotoxins simultaneously and, consequently, to contaminate a wide variety of foodstuffs. Therefore, the risk of human co-exposure to multiple mycotoxins is real, raising a growing concern about their potential impact on human health. Besides, government and industry regulations are usually based on individual toxicities, and do not take into account the complex dynamics associated with interactions between co-occurring groups of mycotoxins. The present work assembles, for the first time, the challenges posed by the likelihood of human co-exposure to these toxins and the possibility of interactive effects occurring after absorption, towards knowledge generation to support a more accurate human risk assessment. Regarding hazard assessment, a physiologically-based framework is proposed in order to infer the health effects from exposure to multiple mycotoxins in food, including knowledge on the bioaccessibility, toxicokinetics and toxicodynamics of single and combined toxins. The prioritisation of the most relevant mixtures to be tested under experimental conditions that attempt to mimic human exposure and the use of adequate mathematical approaches to evaluate interactions, particularly concerning the combined genotoxicity, were identified as the main challenges for hazard assessment. Regarding exposure assessment, the need of harmonised food consumption data, availability of multianalyte methods for mycotoxin quantification, management of left-censored data, use of probabilistic models and multibiomarker approaches are highlighted, in order to develop a more precise and realistic exposure assessment. To conclude, further studies on hazard and exposure assessment of multiple mycotoxins, using harmonised methodologies, are crucial towards an improvement of data quality and a more reliable and robust risk characterisation, which is central for risk management and, consequently, to prevent mycotoxins-associated adverse effects. A deep understanding of the nature of interactions between multiple mycotoxins will contribute to draw real conclusions on the health impact of human exposure to mycotoxin mixtures.pt_PT
dc.description.sponsorshipThis research was performed under the MycoMix project ‘Exploring the toxic effects of mixtures of mycotoxins in infant food and potential health impact’ (PTDC/DTP-FTO/0417/2012), through CESAM: UID/AMB/50017/2013 and ToxOmics: UID/BIM/00009/2013, all funded by the Fundação para a Ciência e Tecnologia (FCT), Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWorld Mycotoxin Journal. 2016;9(5):791-811. doi:10.3920/WMJ2016.2039. Epub 2016 Oct 11pt_PT
dc.identifier.doi10.3920/WMJ2016.2039pt_PT
dc.identifier.issn1875-0710
dc.identifier.urihttp://hdl.handle.net/10400.18/4339
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWageningen Academic Publisherspt_PT
dc.relation.publisherversionhttp://www.wageningenacademic.com/doi/abs/10.3920/WMJ2016.2039pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.subjectMycotoxins Mixturespt_PT
dc.subjectHuman Risk Assessmentpt_PT
dc.subjectCombined Toxicitypt_PT
dc.subjectFood Safetypt_PT
dc.subjectHuman Healthpt_PT
dc.subjectGenotoxicidade Ambiental
dc.titleChallenges in risk assessment of multiple mycotoxins in foodpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0417%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.endPage811pt_PT
oaire.citation.startPage791pt_PT
oaire.citation.titleWorld Mycotoxin Journalpt_PT
oaire.citation.volume9(5)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication7dee8a4a-7112-45ce-a8cb-8c552d7ae061
relation.isProjectOfPublication1d7db62a-6440-4ccb-a5cc-c3f76c8585b3
relation.isProjectOfPublication.latestForDiscovery1d7db62a-6440-4ccb-a5cc-c3f76c8585b3

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