Rare serotype c Haemophilus influenzae invasive isolate: characterization of the first case in Portugal

Bajanca Lavado, Maria Paula; Pinto, Miguel; Carvalho, Maria Dinah; Jantarada Domingos, Gonçalo; Melo-Cristino, José

http://hdl.handle.net/10400.18/10329

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Authors

Bajanca Lavado, Maria Paula

Pinto, Miguel

Carvalho, Maria Dinah

Jantarada Domingos, Gonçalo

Melo-Cristino, José

Abstract(s)

We report for the first time in Portugal a serotype c Haemophilus influenzae isolated from an adult, with HIV-1 infection. Whole-genome sequencing characterized the isolate as clonal complex ST-7, albeit with a novel MLST (ST2754) due to a unique atpG profile. Integration of this genome with other available H. influenzae serotype c genomes from PubMLST revealed its overall genetic distinctiveness, with the closest related isolate being identified in France in 2020. This surveillance study, involving collaboration among hospitals and reference laboratory, successfully contributed to the identification and characterization of this rare serotype.