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Influence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patients

2014-08-29Journal article Restricted access
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dc.contributor.authorTorres, T.
dc.contributor.authorBettencourt, N.
dc.contributor.authorFerreira, J.
dc.contributor.authorCarvalho, C.
dc.contributor.authorMendonca, D.
dc.contributor.authorPinho-Costa, P.
dc.contributor.authorVasconcelos, C.
dc.contributor.authorSelores, M.
dc.contributor.authorSilva, B.
dc.date.accessioned2015-02-17T13:42:51Z
dc.date.available2015-02-17T13:42:51Z
dc.date.issued2014-08-29
dc.descriptionLetter to the Editorpor
dc.description.abstractPsoriasis is a systemic inflammatory disorder associated with numerous medical comorbidities and increased risk of cardiovascular disease (CVD. Psoriasis’ systemic inflammation may play an important role in the accelerated atherosclerosis observed in these patients2 as inflammatory processes play a key role in atherogenesis. Psoriasis and atherosclerosis share some pathological features including endothelial dysfunction, alteration in angiogenesis and some inflammatory pathways. TNF-a is a potent pro-inflammatory cytokine that has been implicated in psoriasis and atherosclerosis pathogenesis and its synthesis is tightly regulated at gene transcription level. TNF-a gene promoter region contains several single-nucleotide polymorphisms (SNP) that influence TNF-a production. Several TNF-a gene polymorphisms have been associated with psoriasis and CVD. A recent meta-analysis suggested that TNF-a rs1800629(308G/A) polymorphism was associated with decreased risk of psoriasis, whereas TNF-a rs361525(238G/A) was associated with increased risk. Regarding TNF-a rs1799964 (1031T/C) polymorphism, existing data are limited and contradictory.8 Since psoriasis morbidity and mortality are strongly linked to accelerated atherosclerosis, determining the genetic contribution for cardiovascular morbidity in psoriasis patients becomes an issue of major importance. The aim of this study was to evaluate the contribution of TNF-a rs361525(238G/A), TNF-a rs1800629(308G/A) and TNFa rs1799964(1031T/C) gene polymorphisms to coronary artery calcification (CAC) in severe psoriasis patients.por
dc.description.sponsorshipThis study was supported in part by an unrestricted grant from the Portuguese Society of Dermatology and Venereology.por
dc.identifier.citationJ Eur Acad Dermatol Venereol. 2016 Jan;30(1):191-3. doi: 10.1111/jdv.12706. Epub 2014 Aug 29por
dc.identifier.doi10.1111/jdv.12706
dc.identifier.issn0926-9959
dc.identifier.urihttp://hdl.handle.net/10400.18/2871
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWiley/ European Academy of Dermatology and Venereologypor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/jdv.12706/fullpor
dc.subjectTNF- a gene Polymorphismspor
dc.subjectCoronary Artery Calcificationpor
dc.subjectPsoriasispor
dc.subjectDoenças Genéticaspor
dc.titleInfluence of TNF-α gene polymorphisms in coronary artery calcification in psoriasis patientspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3por
oaire.citation.startPage1por
oaire.citation.titleJournal of the European Academy of Dermatology and Venereologypor
oaire.citation.volume28por
rcaap.rightsembargoedAccesspor
rcaap.typearticlepor

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