Repository logo
 
Publication

Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification

2014-11-04Journal article Restricted access
Simple item page
dc.contributor.authorDefferrari, R.
dc.contributor.authorMazzocco, K.
dc.contributor.authorAmbros, I.M.
dc.contributor.authorAmbros, P.F.
dc.contributor.authorBedwell, C.
dc.contributor.authorBeiske, K.
dc.contributor.authorBénard, J.
dc.contributor.authorBerbegall, A.P.
dc.contributor.authorBown, N.
dc.contributor.authorCombaret, V.
dc.contributor.authorCouturier, J.B.
dc.contributor.authorErminio, G.
dc.contributor.authorGambini, C.
dc.contributor.authorGaraventa, A.
dc.contributor.authorGross, N.
dc.contributor.authorHaupt, R.
dc.contributor.authorKohler, J.
dc.contributor.authorJeison, M.
dc.contributor.authorLunec, J.
dc.contributor.authorMarques, B.
dc.contributor.authorMartinsson, T.
dc.contributor.authorNoguera, R.
dc.contributor.authorParodi, S.
dc.contributor.authorSchleiermacher, G.
dc.contributor.authorTweddle, D.A.
dc.contributor.authorValent, A.B.
dc.contributor.authorVan Roy, N.
dc.contributor.authorVicha, A.
dc.contributor.authorVillamon, E.
dc.contributor.authorTonini, G.P.
dc.date.accessioned2015-02-04T13:44:05Z
dc.date.available2015-12-01T01:30:09Z
dc.date.issued2014-11-04
dc.description.abstractBACKGROUND: The prognostic impact of segmental chromosome alterations (SCAs) in children older than 1 year, diagnosed with localised unresectable neuroblastoma (NB) without MYCN amplification enrolled in the European Unresectable Neuroblastoma (EUNB) protocol is still to be clarified, while, for other group of patients, the presence of SCAs is associated with poor prognosis. METHODS: To understand the role of SCAs we performed multilocus/pangenomic analysis of 98 tumour samples from patients enrolled in the EUNB protocol. RESULTS: Age at diagnosis was categorised into two groups using 18 months as the age cutoff. Significant difference in the presence of SCAs was seen in tumours of patients between 12 and 18 months and over 18 months of age at diagnosis, respectively (P=0.04). A significant correlation (P=0.03) was observed between number of SCAs per tumour and age. Event-free (EFS) and overall survival (OS) were calculated in both age groups, according to both the presence and number of SCAs. In older patients, a poorer survival was associated with the presence of SCAs (EFS=46% vs 75%, P=0.023; OS=66.8% vs 100%, P=0.003). Moreover, OS of older patients inversely correlated with number of SCAs (P=0.002). Finally, SCAs provided additional prognostic information beyond histoprognosis, as their presence was associated with poorer OS in patients over 18 months with unfavourable International Neuroblastoma Pathology Classification (INPC) histopathology (P=0.018). CONCLUSIONS: The presence of SCAs is a negative prognostic marker that impairs outcome of patients over the age of 18 months with localised unresectable NB without MYCN amplification, especially when more than one SCA is present. Moreover, in older patients with unfavourable INPC tumour histoprognosis, the presence of SCAs significantly affects OS.por
dc.identifier.citationBr J Cancer. 2015 Jan 20;112(2):290-5. doi: 10.1038/bjc.2014.557. Epub 2014 Nov 4por
dc.identifier.doi10.1038/bjc.2014.557
dc.identifier.issn0007-0920
dc.identifier.urihttp://hdl.handle.net/10400.18/2774
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherNature Publishing Grouppor
dc.relation.publisherversionhttp://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2014557a.htmlpor
dc.subjectNeuroblastomapor
dc.subjectSegmental Chromosome abnormalitiespor
dc.subjectMYCN Amplificationpor
dc.subjectDoenças Genéticaspor
dc.titleInfluence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplificationpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage295por
oaire.citation.issueBr J Cancer. 2014 Nov 4. doi: 10.1038/bjc.2014.557. [Epub ahead of print]por
oaire.citation.startPage290por
oaire.citation.titleBritish Journal of Cancerpor
oaire.citation.volume112(2)por
rcaap.rightsembargoedAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
bjc2014557a.pdf
Size:
658.73 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DGH - Artigos em revistas internacionais