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HBM4EU chromates study: the Portuguese integrated and harmonized study on exposure to hexavalent chromium and related early effects.

2024-12-05Research article Open access
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datacite.subject.fosCiências Naturais
dc.contributor.authorViegas, Susana
dc.contributor.authorMartins, Carla
dc.contributor.authorRibeiro, Edna
dc.contributor.authorLadeira, Carina
dc.contributor.authorPinhal, Hermínia
dc.contributor.authorNogueira, Ana
dc.contributor.authorSantos, Sílvia
dc.contributor.authorTavares, Ana
dc.contributor.authorGomes, Bruno Costa
dc.contributor.authorAfonso, Catarina Maia
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria Joao
dc.date.accessioned2025-03-13T11:04:56Z
dc.date.available2025-03-13T11:04:56Z
dc.date.issued2024-12-05
dc.description.abstractIn the scope of the European Union (EU) human biomonitoring initiative, a multicentric study on different occupational settings from several European countries was performed, to provide information on occupational exposure to hexavalent chromium [Cr(VI)], a known lung carcinogen. Biomonitoring approaches were used to obtain exposure data to support the implementation of new risk management measures and policy actions at the national and European levels. This work describes the Portuguese contribution to the study, which aimed to assess workers' exposure to Cr, by using exposure biomarkers (urinary chromium [U-Cr]), and industrial hygiene samples (air and hand wipes) and to link exposure to potential long-term health effects by using effect biomarkers. Exposure determinants influencing exposure were explored from the contextual information and human biomonitoring data. The ultimate goal of the study was to appraise the risk management measures contributing to minimize exposure and protect workers' health. Several occupational settings and activities were considered, including plating, welding, and painting. A control group from the Portuguese general population was also included. Data on age, sex, and smoking habits from both groups were considered in the statistical analysis. Information on the risk management measures available for workers was collected and used to identify the ones that mainly contributed to reduce exposure. Environmental monitoring and human biomonitoring revealed that painters were the highest exposed group. The use of respiratory protection equipment showed an influence on total U-Cr levels for workers involved in painting activities. Concerning early health effects, the painters presented also a significantly higher level of DNA and chromosomal damage in peripheral blood cells, as compared to the control group, suggesting a plausible association between exposure to Cr(VI) and early genotoxic effects. The results showed that workers are exposed to Cr(VI) in those occupational settings. These findings point to the need to improve the prevention and risk management measures and the implementation and enforcement of new regulatory actions at the national level.por
dc.description.abstractWhat’s Important About This Paper? This study provides human biomonitoring information regarding occupational exposure to hexavalent chromium in Portugal that can be used to support the implementation of new and effective risk management measures and policy actions at both national and international levels. The results also highlight the need to update the hexavalent chromium occupational limit value as it is being discussed at the European level.por
dc.description.sponsorshipThis project received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032 (Human Biomonitoring for European Union, HBM4EU) and received co-funding from the authors’ organizations and/ or Ministries.
dc.identifier.citationAnn Work Expo Health. 2025 Feb 25;69(2):147-159. doi: 10.1093/annweh/wxae091
dc.identifier.doihttps://doi.org/10.1093/annweh/wxae091
dc.identifier.issn2398-7308
dc.identifier.pmid39657029
dc.identifier.urihttp://hdl.handle.net/10400.18/10437
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.hasversionhttps://academic.oup.com/annweh/article/69/2/147/7917522?login=false
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectHexavalent Chromium
dc.subjectOccupational Exposure
dc.subjectEnvironmental Genotoxicity
dc.subjectBiomonitoring
dc.subjectEffect Biomarkers
dc.subjectGenotoxicidade Ambiental
dc.subjectAr e Saúde Ocupacional
dc.subjectPortugal
dc.titleHBM4EU chromates study: the Portuguese integrated and harmonized study on exposure to hexavalent chromium and related early effects.
dc.typeresearch article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.endPage159
oaire.citation.issue2
oaire.citation.startPage147
oaire.citation.titleAnnals of Work Exposures and Health
oaire.citation.volume69
oaire.fundingStreamH2020
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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