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Anorectal malformations and pregnancy-related disorders: a registry-based case-control study in 17 European regions

2013-04-10Journal article Restricted access
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dc.contributor.authorWijers, C.H.
dc.contributor.authorvan Rooij, I.A.
dc.contributor.authorBakker, M.K.
dc.contributor.authorMarcelis, C.L.
dc.contributor.authorAddor, M.C.
dc.contributor.authorBarisic, I.
dc.contributor.authorBéres, J.
dc.contributor.authorBianca, S.
dc.contributor.authorBianchi, F.
dc.contributor.authorCalzolari, E.
dc.contributor.authorGreenlees, R.
dc.contributor.authorLelong, N.
dc.contributor.authorLatos-Bielenska, A.
dc.contributor.authorDias, Carlos Matias
dc.contributor.authorMcDonnell, R.
dc.contributor.authorMullaney, C.
dc.contributor.authorNelen, V.
dc.contributor.authorO'Mahony, M.
dc.contributor.authorQueisser-Luft, A.
dc.contributor.authorRankin, J.
dc.contributor.authorZymak-Zakutnia, N.
dc.contributor.authorde Blaauw, I.
dc.contributor.authorRoeleveld, N.
dc.contributor.authorde Walle, H.E.
dc.date.accessioned2014-03-10T13:55:48Z
dc.date.available2014-03-10T13:55:48Z
dc.date.issued2013-04-10
dc.description.abstractOBJECTIVE: To identify pregnancy-related risk factors for different manifestations of congenital anorectal malformations (ARMs). DESIGN: A population-based case-control study. SETTING: Seventeen EUROCAT (European Surveillance of Congenital Anomalies) registries, 1980-2008. POPULATION: The study population consisted of 1417 cases with ARM, including 648 cases of isolated ARM, 601 cases of ARM with additional congenital anomalies, and 168 cases of ARM-VACTERL (vertebral, anal, cardiac, tracheo-esophageal, renal, and limb defects), along with 13 371 controls with recognised syndromes or chromosomal abnormalities. METHODS: Multiple logistic regression analyses were used to calculate adjusted odds ratios (ORs) for potential risk factors for ARM, such as fertility treatment, multiple pregnancy, primiparity, maternal illnesses during pregnancy, and pregnancy-related complications. MAIN OUTCOME MEASURES: Adjusted ORs for pregnancy-related risk factors for ARM. RESULTS: The ARM cases were more likely to be firstborn than the controls (OR 1.6, 95% CI 1.4-1.8). Fertility treatment and being one of twins or triplets seemed to increase the risk of ARM in cases with additional congenital anomalies or VACTERL (ORs ranging from 1.6 to 2.5). Maternal fever during pregnancy and pre-eclampsia were only associated with ARM when additional congenital anomalies were present (OR 3.9, 95% CI 1.3-11.6; OR 3.4, 95% CI 1.6-7.1, respectively), whereas maternal epilepsy during pregnancy resulted in a five-fold elevated risk of all manifestations of ARM (OR 5.1, 95% CI 1.7-15.6). CONCLUSIONS: This large European study identified maternal epilepsy, fertility treatment, multiple pregnancy, primiparity, pre-eclampsia, and maternal fever during pregnancy as potential risk factors primarily for complex manifestations of ARM with additional congenital anomalies and VACTERL.por
dc.identifier.citationBJOG. 2013;120(9):1066-74. Epub 2013 Apr 10por
dc.identifier.issn1470-0328
dc.identifier.otherdoi: 10.1111/1471-0528.12235
dc.identifier.urihttp://hdl.handle.net/10400.18/1986
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWiley/ Royal College of Ostetricians and Gynaecologist (RCOG)por
dc.relationEUROCATpor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/1471-0528.12235/abstract;jsessionid=C70BF193A4ADA8C0D4CEF1D500BCB6CA.f01t03
dc.subjectAnal Atresiapor
dc.subjectVACTERLpor
dc.subjectAetiologypor
dc.subjectBirth Defectspor
dc.subjectRENACpor
dc.subjectMaternalpor
dc.subjectPregnancypor
dc.subjectEstados de Saúde e de Doençapor
dc.titleAnorectal malformations and pregnancy-related disorders: a registry-based case-control study in 17 European regionspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1074por
oaire.citation.startPage1066por
oaire.citation.titleBJOG: An International Journal of Obstetrics and Gynaecologypor
oaire.citation.volume120(9)por
rcaap.rightsembargoedAccesspor
rcaap.typearticlepor

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