Epidemiology of invasive meningococcal disease in Portugal in the last decade – 2007-2016

Simões, Maria João; Betencourt, Célia; Gonçalves, Paulo; Fernandes, Teresa; on behalf of VigLab-DM – Network for the Laboratory Surveillance of Meningococcal Disease

Publication

Epidemiology of invasive meningococcal disease in Portugal in the last decade – 2007-2016

2017-09Conference object

dc.contributor.author	Simões, Maria João
dc.contributor.author	Betencourt, Célia
dc.contributor.author	Gonçalves, Paulo
dc.contributor.author	Fernandes, Teresa
dc.contributor.author	on behalf of VigLab-DM – Network for the Laboratory Surveillance of Meningococcal Disease
dc.date.accessioned	2018-03-05T17:25:52Z
dc.date.available	2018-03-05T17:25:52Z
dc.date.issued	2017-09
dc.description	Abstract disponível em: http://emgm.eu/meetings/emgm2017/emgm-2017-book-of-abstracts.pdf	pt_PT
dc.description.abstract	Introduction: A surveillance system of meningococcal disease (MD) was implemented in Portugal in October 2002, becoming mandatory the clinical and laboratory notification of all cases. By that time, the National Reference Laboratory (NRL) of Neisseria meningitidis at the National Institute of Health Dr. Ricardo Jorge, Lisbon, created a hospital laboratory network, which is still managed by the institute, which supports the laboratory based surveillance of DM. To fulfil this purpose laboratories should send meningococcal isolates as well as negative culture clinical samples from suspected cases for lab confirmation and genotyping to the NRL. Additionally, vaccination against MenC started in 2002 and, in 2006, MenC vaccine was introduced in the national immunization programme, addressed to children under one year of age. Since 2007 the number of invasive C strains became residual. In April 2014 the multi-component vaccine 4CMenB was introduced in the market. Aim: Presenting data of MD surveillance referring to the last decade, 2007–2016. Methods: Confirmation of cases with negative culture was performed by real time PCR targeting ctrA and sodC. Molecular characterization of N. meningitidis, either isolates or DNA from clinical samples, included group, subtype, FetA, ST. Results: In the last decade 764 cases (677 confirmed and 87 possible/probable) of MD were reported in Portugal. The incidence ranged from 1.11 cases per 100,000 inhabitants in 2007 to 0.41 in 2016. The observed decreasing incidence is mainly due to age group under 12 months in which a 66.6% drop in the incidence rate between 2013 and 2016 was observed. Group B has been the most frequent (61.1% in 2014 to 90.5% in 2008 of confirmed cases). Strains Y were the second most frequent, increasing the number of isolates since 2007. Group W and C were residual. Group B strains presented a large genetic diversity. The most common clonal complexes (cc) within B strains were cc41/44 (±25% of all cc), cc269, cc162 and cc213, the latter present in an increasing proportion of cases since 2009. Group Y and C exhibited a clonal character being mostly cc23 and cc11 respectively. Conclusion: The vaccination against MenC was very effective and the number of cases due to C strains became very low since 2007. In the last decade the incidence of MD has being decreasing with a marked decreasing in age group under 12 months of age. Group B was the most frequent and presented a great genetic diversity.	pt_PT
dc.description.version	N/A	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.18/5176
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	pt_PT
dc.subject	Meningococcal Disease	pt_PT
dc.subject	Epidemiology	pt_PT
dc.subject	Portugal	pt_PT
dc.title	Epidemiology of invasive meningococcal disease in Portugal in the last decade – 2007-2016	pt_PT
dc.type	conference object
dspace.entity.type	Publication
oaire.citation.conferencePlace	Prague, Czech Republic	pt_PT
oaire.citation.title	14th Congress of the EMGM, The European Meningococcal and Haemophilus Disease Society, 18-21 September 2017	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	conferenceObject	pt_PT