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Systematic investigation of environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican Nephropathy (MeN)

2019-03Conference object Restricted access
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dc.contributor.authorSmpokou, E.T.
dc.contributor.authorGonzález-Quiroz, M.
dc.contributor.authorMartins, Carla
dc.contributor.authorAlvito, Paula
dc.contributor.authorLe Blond, J.
dc.contributor.authorGlaser, J.
dc.contributor.authorAragón, A.
dc.contributor.authorWesseling, C.
dc.contributor.authorNitsch, D.
dc.contributor.authorPearce, N.
dc.contributor.authorNorman, J.
dc.contributor.authorLindh, C.
dc.contributor.authorMorton, J.
dc.contributor.authorCaplin, B.
dc.date.accessioned2020-05-15T10:26:00Z
dc.date.available2020-05-15T10:26:00Z
dc.date.issued2019-03
dc.description.abstractObjectives: There is an epidemic of Mesoamerican Nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes have been proposed, but to date limited evidence supports any one hypothesis. A nested case-control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN, was conducted with the aim of characterizing the associations between urinary concentrations of metals, pesticides and mycotoxins, and decline in kidney function. Methods: Urine samples collected at baseline (pre-sugarcane harvest) and at the first 6-month follow-up (post-sugarcane harvest) visit were tested. Twelve metals and metalloids (Al, total As, Cd, Co, Cr, Cu, Hg, Mn, Pb, Se, Si and Sr) were analysed by inductively-coupled plasma-mass spectrometry. Twelve pesticides or their metabolites (2,4-D, 3-PBA, 4F3PBA, CFCA, DCCA, ETU, glyphosate, MCPA, OH-PYM, 5-OH-TBZ, TEB-OH and TCP), and two mycotoxins (OTA and CIT), were analysed by liquid chromatography coupled to mass spectrometry. Differences in the creatinine-corrected urinary concentrations of the measured exposures between outcome groups (participants with stable versus declining kidney function over a 2-year follow-up period) were examined. Results: Elevated levels of aluminium and total arsenic as well as metabolites of several pesticides were detected across the population. No differences were identified between the declining and stable groups in the levels of metals or pesticides tested. OTA and CIT were below the limit of detection. Conclusions: These findings provide evidence against the tested metals, metalloids, pesticides and mycotoxins as the primary cause(s) of MeN in Nicaragua.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6662
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectMesoamerican Nephropathypt_PT
dc.subjectKidney Functionpt_PT
dc.subjectMeNpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.titleSystematic investigation of environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican Nephropathy (MeN)pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceSan José, Costa Ricapt_PT
oaire.citation.title3rd International Workshop on Chronic Kidney Diseases of Uncertain/Non-Traditional Etiology in Mesoamerica and Other Regions, 20-22 March 2019pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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