Repository logo
 
Publication

Dietary exposure to aflatoxins in the Portuguese population – the use of biomonitoring data to assess the associated burden

2020-02Conference object Restricted access
Simple item page
dc.contributor.authorMartins, Carla
dc.contributor.authorVidal, Arnau
dc.contributor.authorDe Boevre, M.
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorNunes, Carla
dc.contributor.authorTorres, Duarte
dc.contributor.authorGoios, Ana
dc.contributor.authorLopes, Carla
dc.contributor.authorAlvito, Paula
dc.contributor.authorAssunção, Ricardo
dc.date.accessioned2021-04-21T15:48:54Z
dc.date.available2021-04-21T15:48:54Z
dc.date.issued2020-02
dc.description.abstractBackground: Human biomonitoring (HBM) is an important tool to assess the human exposure to chemicals, contributing to describe trends of exposure over time and to identify population groups that could be under risk. Aflatoxins (AFTs) are genotoxic and carcinogenic compounds causing hepatocellular carcinoma (HCC), the third leading cause of cancer deaths worldwide. In Portugal, scarce data are available regarding exposure to AFTs and none previous study used HBM data to characterize comprehensively the associated burden. Methods: 24h-urine samples (n=94) were analyzed by liquid chromatography–mass spectrometry (LC-MS/MS) for the determination of AFTs (B1, B2, G1, G2, M1). Regarding left-censored data (< LOD) a substitution approach was considered (< LOD = 0). Deterministic and probabilistic models were developed to estimate the health impact of the exposure to aflatoxins, estimating the DALYs attributed to AFTs exposure for the Portuguese population (10291k). Results: AFTs were detected in 13% (AFB1), 16% (AFB2), 1% (AFG1), 2% (AFG2) and 19% (AFM1) of the 24h-urine samples. The mean probable daily intake estimated was 16.7 and 13.4 ng/kg body weight/day, calculated mean DALYs/100k were 1.7 (0-10.7) and 1.68 (0.04-6.23) considering the deterministic and probabilistic models, respectively. Conclusion: The present study generated, for the first time and within a HBM study, reliable and crucial data to characterize the burden associated to Portuguese population exposure to aflatoxins. The obtained results constitute an important contribution to support risk managers in the establishment of preventive policy measures that contribute to ensure the public health protection.pt_PT
dc.description.sponsorshipThanks are due to FCT/MCTES for the financial support to CESAM (UID/AMB/50017/2019), through national funds. This research was also supported by the project MYTOX-SOUTH, Ghent University Global Minds programme. IAN-AF national survey was funded by the EEA Grants Program, Public Health Initiatives (PT06 - 000088SI3)pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7681
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAflatoxinspt_PT
dc.subjectExposure to Chemicalspt_PT
dc.subjectPortuguese Populationpt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.subjectPortugalpt_PT
dc.titleDietary exposure to aflatoxins in the Portuguese population – the use of biomonitoring data to assess the associated burdenpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT (2019)
oaire.citation.conferencePlaceCopenhaga, Dinamarcapt_PT
oaire.citation.title1st WG meeting & 2nd MC meeting 'Burden of Disease in Europe - Taking stock and moving forward', National Food Institute, Technical University of Denmark, 18-19 February 2020pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicationf076fef9-580b-485a-9a0e-c5a599424c6e
relation.isProjectOfPublication.latestForDiscoveryf076fef9-580b-485a-9a0e-c5a599424c6e

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2020, Poster, Dietary exposure to aflatoxins in the Portuguese population – the use of biomonitoring data to assess the associated burden.pdf
Size:
682.79 KB
Format:
Adobe Portable Document Format
Download

Collections

DAN - Posters/abstracts em congressos internacionais