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Projeto de investigação
A PeRsOnalized Prevention roadmap for the future HEalThcare
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Implementation of genetic tests for disease prevention: challenges in evidence synthesis across clinical utility domains
Publication . Gris, Angelica Valz; Vicente, Astrid M.; Boccia, Stefania
Excerpt: Robust evidence supports the critical role of genetic risk in shaping the frequency of a broad range of diseases, underscoring its significance as a determinant of health outcomes [1]. Accordingly, genetic and genomic tests hold significant potential for disease prevention by stratifying populations based on individual genetic profiles and guiding targeted interventions. However, despite the enthusiasm surrounding these technologies, their integration into preventive healthcare faces significant hurdles, primarily due to the insufficient evidence supporting their clinical utility [2]. Clinical utility, though not universally defined, generally refers to the test’s usefulness to provide actionable information that improves health outcomes. (...)
The PROPHET Framework for Personalised Prevention
Publication . Vicente, Astrid Moura
The PROPHET Framework proposed consists in a multidimensional appraisal framework for personalised prevention initiatives, with a sequential approach of Health Technology Assessment, Health Impact Assessment, and Monitoring. This integration bridges technical, clinical, and societal dimensions, ensuring that personalized prevention strategies are not only effective but also equitable and sustainable in real-world settings.
A multi-stakeholder perspective on Barriers to the adoption of personalized prevention in European healthcare systems
Publication . Costa, Alexandra; Cardoso, Maria Luís; Carvalho, Adriana Reimão; Osti, Tommaso; Farina, Sara; Taha, Abdelrahman; Savoia, Cosimo; Russo, Luigi; Maio, Alessandra; Scarsi, Nicolò; Flodkvist, Evelina; Gyllenberg, Alexandra; Boccia, Stefania; Vicente, Astrid Moura
Introduction: Personalized prevention is an important component of personalized medicine, tailoring interventions to the biological, behavioral, sociocultural and environmental characteristics of individuals for the prevention of disease onset, progression and recurrence. Despite its potential, personalized preventive interventions (PPI) remain less commonly implemented in clinical practice. This study explored the main barriers to a broader adoption of PPI in European healthcare systems.
Methods: A multi-stakeholder consultation involving citizens/patients, health professionals, researchers, and policymakers was conducted using a sequential mixed-methods approach. In the first phase, semi-structured interviews with key informants representing different stakeholder groups were conducted. The thematic analysis of interview findings, complemented by insights from a review of the literature, informed the development of an online survey implemented in the second phase of the study.
Twenty-six interviews and 270 complete surveys were analyzed. Stakeholders identified barriers across three main domains: (1) healthcare systems, (2) implementation, and (3) awareness, education, and literacy. Key barriers associated with limited PPI adoption included the predominant focus of health strategies on treatment over prevention, unresolved ethical, legal, and social issues (ELSI), limited awareness and knowledge of personalized prevention among both professionals and citizens, and the lack of appropriate cost–benefit evaluation models.
Findings highlight interconnected barriers that may impact a broader PPI adoption across healthcare system, governance, implementation, and awareness-related domains. Continued stakeholder dialogue and engagement, alongside efforts to address awareness and governance-related challenges, may support the broader integration of PPI into European healthcare systems.
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Entidade financiadora
European Commission
Programa de financiamento
HORIZON Coordination and Support Actions
Número da atribuição
101057721