A multiscale approach towards mesostructured porous material design

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Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion

Publication . Del Campo, Ruben; Savoini, Begona; Jordao, Luisa; Munoz, A; Monge, M A

In this work the cytocompatibility of pure magnesiumandMg-xHAP composites (x=5, 10 and 15wt%) fabricated by powder metallurgy routes has been investigated. The materials were produced from raw HAP powders with particle mean sizes of 6 μm (S-xHAP) or 25 μm (L-xHAP). The biocompatibility study has been performed forMC3T3 cells (osteoblasts/osteoclasts) and L929 fibroblasts. The results indicate that S-Mg (pure magnesium), S-10HAP and L-10HAP composites are the materials with the best biocompatibility. The ability of S. aureus bacteria to assemble biofilms was also evaluated. Biofilm formation assays showed that these materials are not particular prone to colonization and biofilm assembly is strain dependent. The corrosion resistance of S-Mg, S-10HAP and L-10HAP materials immersed in the media used for the cells culture has also been analyzed. Different trends in the corrosion resistance have been found: S-Mg and S-10HAP showa very high resistance to corrosionwhereas the corrosion of L-10HAP steadily increases with time.

2017-09-01Journal article

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