Browsing by Issue Date, starting with "2014-05-16"
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- Nanomateriais Manufaturados: avaliação de efeitos genotóxicosPublication . Louro, Henriqueta; Silva, Maria JoãoConteúdo da Aula: -Definição de nanomaterial -Propriedades dos nanomateriais -Nanomateriais Manufaturados -Possíveis vias de exposição a NM -Potenciais efeitos dos NM na saúde -O comportamento dinâmico dos NM -Interações NM - sistemas biológicos -A Nanotoxicologia -Genotoxicidade dos Nanomateriais -Avaliação de segurança dos NMs através da caracterização dos seus efeitos genéticos -- Estudos realizados In vitro -- Estudos realizados In vivo -- Conclusões dos estudos in vitro e in vivo
- Projeto HERA - Avaliação do potencial genotóxico de sedimentos dum ambiente estuarino contaminadoPublication . Pinto, Miguel; Louro, Henriqueta; Silva, Maria JoãoEstudo de caso: Avaliação do potencial genotóxico de sedimentos dum ambiente estuarino contaminado.
- A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermiaPublication . Seabra, Catarina M.; Quental, Sofia; Paula Neto, Ana; Carvalho, Filipa; Gonçalves, João; Paulo Oliveira, João; Fernandes, Susana; Sousa, Mário; Barros, Alberto; Amorim, António; Lopes, Alexandra M.This article describes a patient with cryptorchidism and nonobstructive azoospermia presenting a novel microdeletion of approximately 1 Mb at 11p13. It was confirmed by multiplex ligation-dependent probe amplification that this heterozygous deletion spanned nine genes (WT1, EIF3M, CCDC73, PRRG4, QSER1, DEPDC7, TCP11L1, CSTF3 and HIPK3) and positioned the breakpoints within highly homologous repetitive elements. As far as is known, this is the smallest deletion as-yet described encompassing the WT1 gene and was detected only once in a total of 32 Portuguese patients with isolated uni- or bilateral cryptorchidism. These findings suggest that molecular analysis in patients with genitourinary features suggestive of WT1 impairment, namely cryptorchidism and renal abnormalities, may reveal cryptic genetic defects.
- Case study: Multi-mycotoxin determination in baby foods and in vitro combined cytotoxic effects of aflatoxin M1 and ochratoxin APublication . Tavares, Ana; Louro, Henriqueta; Silva, Louro
- Estudos de biomonitorização humana: exemplo de aplicação práticaPublication . Silva, Maria João; Louro, HenriquetaAplicação prática ao estudo do efeito do fumo de tabaco ambiental em estabelecimentos de restauração de Lisboa.
- Economics of Chronic Diseases Protocol: Cost-effectiveness modelling and the future burden of non-communicable disease in EuropePublication . Divajeva, D.; Marsh, T.; Logstrup, S.; Kestens, M.; Vemer, P.; Kriaucioniene, V.; Peresson, S.; O’Kelly, S.; Rito, A.; Webber, L.Background: The majority of chronic disease is caused by risk factors which are mostly preventable. Effective interventions to reduce these risks are known and proven to be applicable to a variety of settings. Chronic disease is generally developed long before the fatal outcome, meaning that a lot of people spend a number of years in poor health. Effective prevention measures can prolong lives of individuals and significantly improve their quality of life. However, the methods to measure cost-effectiveness are a subject to much debate. The Economics of Chronic Diseases project aims to establish the best possible methods of measuring cost-effectiveness as well as develop micro-simulation models apt at projecting future burden of chronic diseases, their costs and potential savings after implementation of cost-effective interventions. Method: This research project will involve eight European countries: Bulgaria, Finland, Greece, Lithuania, The Netherlands, Poland, Portugal and the United Kingdom (UK). A literature review will be conducted to identify scientific articles which critically review the methods of cost-effectiveness. Contact will be made health economists to inform and enrich this review. This evidence will be used as a springboard for discussion at a meeting with key European stakeholders and experts with the aim of reaching a consensus on recommendations for cost-effectiveness methodology. Epidemiological data for coronary heart disease, chronic kidney disease, type 2 diabetes and chronic obstructive pulmonary disease will be collected along with data on time trends in three major risk factors related to these diseases, specifically tobacco consumption, blood pressure and body mass index. Economic and epidemiological micro-simulation models will be developed to asses the future distributions of risks, disease outcomes, healthcare costs and the cost-effectiveness of interventions to reduce the burden of chronic diseases in Europe. Discussion: This work will help to establish the best methods of measuring cost-effectiveness of health interventions as well as test a variety of scenarios to reduce the risk factors associated with selected chronic diseases. The modelling projections could be used to inform decisions and policies that will implement the best course of action to curb the rising incidence of chronic diseases.
- Métodos de avaliação de efeitos genotóxicos e suas aplicaçõesPublication . Louro, Henriqueta; Silva, Maria JoãoConteúdo da Aula: -Toxicologia Genética -Enquadramento da Experimentação Animal em Toxicologia Genética -Aplicações de modelos de ratinhos transgénicos -Construção de um ratinho transgénico -Modelos de ratinhos transgénicos para estudos de genotoxicidade -O ratinho transgénico baseado em plasmideo contendo o gene LacZ -Exemplos de Aplicações dos Modelos de ratinhos transgénicos -Ratinhos geneticamente modificados para ensaios de carcinogenicidade