Percorrer por autor "de Menezes, Alexandre"
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- Mapping the evidence of the effects of environmental factors on the prevalence of antibiotic resistance in the non-built environmentPublication . Deza-Cruz, Iñaki; de Menezes, Alexandre; Gardner, Brian; Aktan, Ílknur; Alnajjar, Sarhad; Betson, Martha; Cabal Rosel, Adriana; Caniça, Manuela; Chambers, Mark A.; Tarrant, Georgina; Contadini, Francesca; Daramola, Olukayode; de la Rivière, Rani; Egan, Bernadette; Ekiri, Abel; Finnegan, Catherine; Gonzalez Villeta, Laura C.; Green, Richard; Hall, Belinda; Hassan, Marwa M.; Hawes, Martin; Healy, Sara; Holbrook, Lisa; Kaya, Damla; Kumar, Prashant; La Ragione, Roberto M.; Maupin, Daniel; Mehat, Jai W.; Messina, Davide; Moon, Kelly; Mumford, Elizabeth; Nichols, Gordon; Olivença, Daniel V.; Prada, Joaquin M.; Price, Claire; Proudman, Christopher; Queenan, Retha; Ramos, Miguel; Closa, Jaime Riccomini; Ritchie, Jennifer M.; Santorelli, Lorenzo A.; Selemetas, Nick; Spick, Matt; Subbannayya, Yashwanth; Surendran, Shelini; Teixeira, Pedro; Tharmakulasingam, Mukunthan; Valle, Damian; van Vliet, Arnoud H.M.; Videira, Marco; Wallace-Williams, Hazel; Wanelik, Klara M.; Woegerbauer, Markus; Wright, Sydney; Lo Iacono, GiovanniBackground: Antibiotic resistance increasingly threatens the interconnected health of humans, animals, and the environment. While misuse of antibiotics is a known driver, environmental factors also play a critical role. A balanced One Health approach-including the environmental sector-is necessary to understand the emergence and spread of resistance. Methods: We systematically searched English-language literature (1990-2021) in MEDLINE, Embase, and Web of Science, plus grey literature. Titles, abstracts, and keywords were screened, followed by full-text reviews using a structured codebook and dual-reviewer assessments. Results: Of 13,667 records screened, 738 met the inclusion criteria. Most studies focused on freshwater and terrestrial environments, particularly associated with wastewater or manure sources. Evidence of research has predominantly focused on Escherichia coli and Pseudomonas spp., with a concentration on ARGs conferring resistance to sulphonamides (sul1-3), tetracyclines (tet), and beta-lactams. Additionally, the People's Republic of China has produced a third of the studies-twice that of the next country, the United States-and research was largely domestic, with closely linked author networks. Conclusion: Significant evidence gaps persist in understanding antibiotic resistance in non-built environments, particularly in marine, atmospheric, and non-agricultural settings. Stressors such as climate change and microplastics remain notably under-explored. There is also an urgent need for more research in low-income regions, which face higher risks of antibiotic resistance, to support the development of targeted, evidence-based interventions.
- Mapping the evidence of the effects of environmental factors on the prevalence of antibiotic resistance in the non-built environment: Protocol for a systematic evidence mapPublication . Gardner, Brian; Betson, Martha; Cabal Rosel, Adriana; Caniça, Manuela; Chambers, Mark A.; Contadini, Francesca M.; Gonzalez Villeta, Laura C.; Hassan, Marwa M.; La Ragione, Roberto M.; de Menezes, Alexandre; Messina, Davide; Nichols, Gordon; Olivença, Daniel V.; Phalkey, Revati; Prada, Joaquin M.; Ruppitsch, Werner; Santorelli, Lorenzo A.; Selemetas, Nick; Tharmakulasingam, Mukunthan; M. van Vliet, Arnoud H.; Woegerbauer, Markus; Deza-Cruz, Iñaki; Lo Iacono, GiovanniBackground: Human, animal, and environmental health are increasingly threatened by the emergence and spread of antibiotic resistance. Inappropriate use of antibiotic treatments commonly contributes to this threat, but it is also becoming apparent that multiple, interconnected environmental factors can play a significant role. Thus, a One Health approach is required for a comprehensive understanding of the environmental dimensions of antibiotic resistance and inform science-based decisions and actions. The broad and multidisciplinary nature of the problem poses several open questions drawing upon a wide heterogeneous range of studies. Objective: This study seeks to collect and catalogue the evidence of the potential effects of environmental factors on the abundance or detection of antibiotic resistance determinants in the outdoor environment, i.e., antibiotic resistant bacteria and mobile genetic elements carrying antibiotic resistance genes, and the effect on those caused by local environmental conditions of either natural or anthropogenic origin. Methods: Here, we describe the protocol for a systematic evidence map to address this, which will be performed in adherence to best practice guidelines. We will search the literature from 1990 to present, using the following electronic databases: MEDLINE, Embase, and the Web of Science Core Collection as well as the grey literature. We shall include full-text, scientific articles published in English. Reviewers will work in pairs to screen title, abstract and keywords first and then full-text documents. Data extraction will adhere to a code book purposely designed. Risk of bias assessment will not be conducted as part of this SEM. We will combine tables, graphs, and other suitable visualisation techniques to compile a database i) of studies investigating the factors associated with the prevalence of antibiotic resistance in the environment and ii) map the distribution, network, cross-disciplinarity, impact and trends in the literature.