Browsing by Author "Moraes de Andrade, Vanessa"
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- Assessment of DNA damage in a group of professional dancers during a 10-month dancing seasonPublication . Esteves, Filipa; Teixeira, Eduardo; Amorim, Tânia; Costa, Carla; Pereira, Cristiana Costa; Fraga, Sónia; Moraes de Andrade, Vanessa; Teixeira, João Paulo; Costa, SolangeIntroduction: Professional dance is an activity with high artistic and physical demands. Requires physical athletic attributes such as muscular strength, endurance, coordination, agility and swiftness. Regular physical activity brings a lot of positive health-related outcomes. Reduce the risk of numerous health disorders like cardiovascular diseases, cancer, hypertension, diabetes, bone and joint diseases and it is responsible to maintain a numerous psychosocial benefits. However, intensive physical exercise is associated with an increased production of free radicals that may overcome the antioxidant system capacity to maintain homeostasis and may react with different biomolecules, e.g. deoxyribonucleic acid (DNA), inducing oxidative damage that may disturb the cell genomic integrity and cause a lot of diseases. The aim of the present study was to evaluate both DNA damage and oxidative stress in a group of professional dancers before and after a 10-month dancing season
- Assessment of DNA damage in a group of professional dancers during a 10-month dancing seasonPublication . Esteves, Filipa; Teixeira, Eduardo; Amorim, Tânia; Costa, Carla; Pereira, Cristiana Costa; Fraga, Sónia; Moraes de Andrade, Vanessa; Teixeira, João Paulo; Costa, SolangeDespite the numerous health benefits of physical activity, some studies reported that increased intensity and duration may induce oxidative stress in several cellular components including DNA. The aim of this study was to assess the level of basal DNA damage as well as oxidative DNA damage in a group of professional dancers before and after a 10-month dancing season. A group of individuals from general population was also assessed as a control. The alkaline version of the comet assay was the method selected to measure both basal DNA damage and oxidative stress, since this method quantifies both endpoints. In order to measure oxidative stress, the comet assay was coupled with a lesion-specific endonuclease (formamidopyrimidine glycosylase) to detect oxidized purines. The levels of oxidative DNA damage in dancers were significantly increased after the dancing season. Pre-season levels of oxidative DNA damage were lower in dancers than those obtained from the general population, suggesting an adaptation of antioxidant system in dancers. Results of the present biomonitoring study indicate the need for more effective measures to protect ballet dancers from potentially occupational health risks related to regular intensive physical exercise.