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Browsing by Author "Minetti, Corrado"

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  • Genomic epidemiology of fluoroquinolone-resistant strains of Shigella sonnei and Shigella flexneri in the Iberian Peninsula from 2015 to 2022
    Publication . Jacqueline, Camille; Minetti, Corrado; Monzon Fernandez, Sara; Silveira, Leonor; Cuesta De La Plaza, Isabel; Pista, Ângela; Herrera-Leon, Silvia
    Fluoroquinolone-resistance in Shigella is among the serious antimicrobial resistance (AMR) threats. We investigated the genomic epidemiology of fluoroquinolone resistant (FQR) strains of S. sonnei and S. flexneri from 2015 to 2022 in Spain and Portugal. We determined the AMR profiles of 416 isolates (S. flexneri and S. sonnei) and FQR isolates were subjected to whole-genome sequencing. The percentage of FQR isolates gradually increased to reach 38% and 80% of S. flexneri and S. sonnei isolates, respectively in 2022. S. sonnei isolates from men were significantly more likely to be FQR (RR = 4.9, 95% CI = 2.7- 9.0). Genomic analysis revealed two major genetic clusters of FQR S. sonnei from the CipR.MSM5 lineage, previously associated with extreme antimicrobial resistance and transmission in men having sex with men. This study contributes to a better understanding of FQR shigellosis transmission and highlights the added value of enhanced surveillance for these pathogens.
    2024-11-29Research article Restricted access Show more
  • Prevention, protocols, and lab capacity: lessons from a norovirus outbreak in the Algarve
    Publication . Sá, Regina; Roque, Joana; Marques Mendes, Pedro; Gonçalves, Inês; Sousa, Judite; Matos, Cátia; Júnior, Álvaro; Coelho, Anabela; Belo Correia, Cristina; Manageiro, Vera; Minetti, Corrado; de Sousa, Rita; Horta Correia, Filomena; Lopes, Carlos; Fonseca, Ana; Almeida, Soraia; Ferreira, Maria Jesus; Almendra, Tiago; des Neves, Natalie; Fernandes, Aida; Queiroz, Carolina; Maia, Carla; Bodião, Joaquim; Guerreiro, Ana Cristina
    This brief report presents the findings of an epidemiological investigation into a large-scale outbreak of norovirus gastroenteritis that occurred in a hotel in Algarve, Portugal, in August 2022. A total of 244 cases were reported, primarily affecting Portuguese families, with the parents aged 40-50 years and the children aged 0-19 years. Reported symptoms included vomiting, nausea, abdominal pain, and diarrhoea. Norovirus genotype GI.3 [P3] was detected in stool samples from eight probable cases, while food samples tested negative for norovirus and common pathogenic bacteria. The investigation data collected suggest that the source of the outbreak was likely in the hotel's common areas, with subsequent person-to-person transmission in other areas. The final report emphasizes the importance of improving outbreak prevention and control measures, including the development of a foodborne outbreak investigation protocol, the establishment of an outbreak response team, and the enhancement of regional laboratory capacity.
    2023-11-28Journal article Restricted access Show more