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  • Human immunodeficiency virus infection may be a contributing factor to monkeypox infection: Analysis of a 42-case series
    Publication . Alpalhão, Miguel; Sousa, Diogo; Frade, Joana Vieitez; Patrocínio, João; Garrido, Pedro Miguel; Correia, Catarina; Brazão, Cláudia; Mancha, Dora; Núncio, Maria Sofia; Carvalho, Isabel Lopes; Pelerito, Ana; Borrego, Maria José; Filipe, Paulo
    To the Editor: An outbreak of monkeypox has emerged, and more than 13,000 cases have already been confirmed worldwide. In our department, we have 42 confirmed cases so far. All of them are cisgender males presenting with lesions in the genital, perianal, or perioral areas (Fig 1). Interestingly, we observe a disproportionate number of individuals living with the human immunodeficiency virus (HIV). Below, we present a retrospective analysis of our confirmed cases with their clinical and epidemiological characteristics (Table I). Differences between groups were analyzed using the Mann–Whitney U test and the t-test for discrete variables according to distribution. Independence between categorical variables was assessed with Fisher's exact test. All tests were performed for a confidence level of 95% in SPSS 22 (IBM Statistics) [...].
    2022-09-22Artigo científico Acesso restrito Ver mais
  • A New World disease: Dual diagnostic challenges in travelers returning from Costa Rica
    Publication . Brazão, Cláudia; Borges-Costa, João; Antunes-Duarte, Sofia; Mancha, Dora; Sun, Lanyu; Marques, Tiago; Gargaté, Maria João; Vilares, Anabela; Reis, Tânia; de Vasconcelos, Pedro; Soares-de-Almeida, Luís; Filipe, Paulo
    Cutaneous diseases in returning travelers encompass a wide spectrum of etiologies and often pose diagnostic challenges. We present the cases of a 50-year-old man and a 57-year-old woman who presented with a 3-month history of erythematous, ulcerated plaques with well-defined elevated borders and a necrotic center on the lower limbs that began 3 weeks after returning from vacation in Costa Rica. Cutaneous biopsy revealed epidermal ulceration and extensive caseating granulomas throughout the full thickness of the dermis. Giemsa staining revealed no amastigotes. Microbiological examinations identified Leishmania braziliensis and excluded mycobacteria and fungi. The diagnosis of cutaneous Leishmaniasis was established. Owing to clinical severity and antimonial unavailability, the man was treated with liposomal amphotericin B. The woman underwent surgical excision of the single lesion, along with oral fluconazole. Complete resolution was documented in both patients. These cases, which posed diagnostic and therapeutic challenges, highlight that cutaneous leishmaniasis, in all its versatile and often perplexing presentations, is a parasitic infection that should always be considered in dermatologic patients returning from vacation in endemic countries.
    2025-05-01Artigo científico Acesso aberto Ver mais