Browsing by Author "Kaesbohrer, Annemarie"
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- Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and PerspectivesPublication . Perestrelo, Sara; Amaro, Ana; Brouwer, Michael S.M.; Clemente, Lurdes; Ribeiro Duarte, Ana Sofia; Kaesbohrer, Annemarie; Karpíšková, Renata; Lopez-Chavarrias, Vicente; Morris, Dearbháile; Prendergast, Deirdre; Pista, Angela; Silveira, Leonor; Skarżyńska, Magdalena; Slowey, Rosemarie; Veldman, Kees T.; Zając, Magdalena; Burgess, Catherine; Alvarez, JulioAntimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC β-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.
- Communicating and disseminating One Health: successes of the One Health European Joint ProgrammePublication . Taylor, Emma; Artursson, Karin; Busani, Luca; Callegari, Arnaud; Cantlay, Jennifer; Caniça, Manuela; Campling, Elaine; Gavier-Widén, Dolores; van de Giessen, Arjen; Itier, David; Imberechts, Hein; Roest, Hendrik-Jan; Jestin, André; de Juan, Lucia; Jokelainen, Pikka; Kaesbohrer, Annemarie; Lindberg, Ann; Mantovani, Alberto; Mølbak, Kåre; van der Poel, Wim H.M.; Poirier, Aurore C.; Sepe, Ludovico P.; Morabito, Stefano; Whitehouse, Jack; Horton, Daniel L.; La Ragione, RobertoThe application of a One Health approach recognizes that human health, animal health, plant health and ecosystem health are intrinsically connected. Tackling complex challenges associated with foodborne zoonoses, antimicrobial resistance, and emerging threats is imperative. Therefore, the One Health European Joint Programme was established within the European Union research programme Horizon 2020. The One Health European Joint Programme activities were based on the development and harmonization of a One Health science-based framework in the European Union (EU) and involved public health, animal health and food safety institutes from almost all EU Member States, the UK and Norway, thus strengthening the cooperation between public, medical and veterinary organizations in Europe. Activities including 24 joint research projects, 6 joint integrative projects and 17 PhD projects, and a multicountry simulation exercise facilitated harmonization of laboratory methods and surveillance, and improved tools for risk assessment. The provision of sustainable solutions is integral to a One Health approach. To ensure the legacy of the work of the One Health European Joint Programme, focus was on strategic communication and dissemination of the outputs and engagement of stakeholders at the national, European and international levels.