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- Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant dataPublication . Holmes, M.V.; Dale, C.E.; Zuccolo, L.; et al.; InterAct ConsortiumTo use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. DESIGN: Mendelian randomisation meta-analysis of 56 epidemiological studies.