Browsing by Author "Guglielmetti, Lorenzo"
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- Limited Benefit of the New Shorter Multidrug-Resistant Tuberculosis Regimen in Europe [Letters to the Editor]Publication . Lange, Christoph; Duarte, Raquel; Fréchet-Jachym, Mathilde; Guenther, Gunar; Guglielmetti, Lorenzo; Olaru, Ioana D; Oliveira, Olena; Rumetshofer, Rudolf; Veziris, Nicolas; van Leth, Frank; European MDR-TB database collaborationExtract: The emergence of multidrug-resistant tuberculosis (MDR-TB), defined as bacillary resistance to at least rifampicin and isoniazid, threatens global TB control. The number of patients notified with MDR-TB worldwide has increased by 261% from 2009 to 2014, and more than one-third of these patients currently live in the European Region of the World Health Organization (WHO). Management of patients with MDR-TB is challenging owing to the long duration of therapy required to achieve a relapse-free cure, complex drug regimens, frequent drug-related adverse events, high costs, suboptimal adherence, and overall low cure rates. [...]