Logo do repositório

Percorrer por autor "Ferreira, Stephanie"

A mostrar 1 - 2 de 2
  • Commentary: Theileria Parasites Secrete a Prolyl Isomerase to Maintain Host Leukocyte Transformation
    Publication . Fernandes, Ruben; Ferreira, Stephanie; Botelho, Mónica C.
    The genus Theileria comprises apicomplexan parasites that are tick-transmitted and infect ruminants with important trade and industry impact in endemic countries. Infectious agents build up elaborate machinery to work together by means of host cell pathways and takeover their genetic and epigenetic mechanisms to modify phenotypic status of host cells. Among the Apicomplexa phylum encompassing obligate intracellular parasites, the only genus that introduces its DNA into mammalian host cells is Theileria, which is known to cause veterinary and human diseases. Various species, including Theileria parva and Theileria annulata, infect leukocytes causing alterations in their phenotypes that are common with several cancers, remarkably immortalization, hyperproliferation, and spreading. (...)
    2018-04-27Artigo científico Acesso aberto Ver mais
  • Fasciola Hepatica Extract Induces Cell Death of Mammalian Cells
    Publication . Ferreira, Stephanie; Fernandes, Ruben; Botelho, Monica C
    Background: Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries. In the world, it has been estimated that at least 2.6 million people are affected with this disease. The International agency for Research on Cancer, states that O. viverrini and C. sinensis, also liver flukes, are considered as definitive causes of cholangiocarcinoma. However, fascioliasis caused by F. hepatica has not been associated with cancer to date. There are not any known causative associations between this parasite and liver cancer (cholangiocarcinoma). Methods: Chine Hamster Ovary (CHO) cells were treated with F. haepatica extracts and cell proliferation was assessed by using the indirect method for estimating cell number based on the mitochondrial activity with MTS cell proliferation reagent. We observed unexpected death of these cells when treated with F. haepatica extracts. Results and Conclusion: We now hypothesize that this parasite could be used as a medically-important trematode pathogen in cancer therapy.
    2018-08Artigo científico Acesso restrito Ver mais