Percorrer por autor "Domingos, C."
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- Emergence of the Asian lineage of Zika virus in Angola: an outbreak investigationPublication . Hill, S.C.; Vasconcelos, J.; Neto, Z.; Jandondo, D.; Zé-Zé, L.; Aguiar, R.S.; Xavier, J.; Thézé, J.; Mirandela, M.; Micolo Cândido, A.L.; Vaz, F.; Sebastião, C.D.S.; Wu, C.H.; Kraemer, M.U.G.; Melo, A.; Schamber-Rei, B.L.F.; de Azevedos, G.S.; Tanuri, T.; Higa, L.M.; Clemente, C.; da Silva, S.P.; da Silva Candido, D.; Claro, I.M.; Quibuco, D.; Domingos, C.; Pocongo, B.; Watts, A.G.; Khan, K.; Alcantara, L.C.J.; Sabino, E.C.; Lackritz, E.; Pybus, O.G.; Alves, M.J.; Afonso, J.; Faria, N.R.Background: Zika virus infections and suspected microcephaly cases have been reported in Angola since late 2016, but no data are available about the origins, epidemiology, and diversity of the virus. We aimed to investigate the emergence and circulation of Zika virus in Angola. Methods: Diagnostic samples collected by the Angolan Ministry of Health as part of routine arboviral surveillance were tested by real-time reverse transcription PCR by the Instituto Nacional de Investigação em Saúde (Ministry of Health, Luanda, Angola). To identify further samples positive for Zika virus and appropriate for genomic sequencing, we also tested samples from a 2017 study of people with HIV in Luanda. Portable sequencing was used to generate Angolan Zika virus genome sequences from three people positive for Zika virus infection by real-time reverse transcription PCR, including one neonate with microcephaly. Genetic and mobility data were analysed to investigate the date of introduction and geographical origin of Zika virus in Angola. Brain CT and MRI, and serological assays were done on a child with microcephaly to confirm microcephaly and assess previous Zika virus infection. Findings: Serum samples from 54 people with suspected acute Zika virus infection, 76 infants with suspected microcephaly, 24 mothers of infants with suspected microcephaly, 336 patients with suspected dengue virus or chikungunya virus infection, and 349 samples from the HIV study were tested by real-time reverse transcription PCR. Four cases identified between December, 2016, and June, 2017, tested positive for Zika virus. Analyses of viral genomic and human mobility data suggest that Zika virus was probably introduced to Angola from Brazil between July, 2015, and June, 2016. This introduction probably initiated local circulation of Zika virus in Angola that continued until at least June, 2017. The infant with microcephaly in whom CT and MRI were done had brain abnormalities consistent with congenital Zika syndrome and serological evidence for Zika virus infection. Interpretation: Our analyses show that autochthonous transmission of the Asian lineage of Zika virus has taken place in Africa. Zika virus surveillance and surveillance of associated cases of microcephaly throughout the continent is crucial.
- Self-reported dermal effects of hand sanitisers in industrial workersPublication . Costa, Carla; Carvalhais, C.; Domingos, C.; Oliveira, A.; Santos, J.Background: During COVID-19 pandemic, preventing the virus spread was extremely important to reduce the overall burden of the disease, to maintain the companies running and to remain safe. WHO recommended physical distances, appropriate use of personal protective equipment and hand hygiene practices to reduce the spread. Hand hygiene practice by using alcohol-based hand sanitisers was generalized in all sectors of activity, including those with no previous need to implement preventive measures against biological risks. Objective: The aim of this study was to obtain self-reported data on hand hygiene habits and perceived symptomatology regarding skin health effects associated with skin exposure to alcohol-based hand sanitisers of industrial workers during COVID-19 pandemic. Method: Between November 2021 and April 2022, a questionnaire-based descriptive cross-sectional study was conducted using 97 study participants. Results: The reported information on hands sanitisers used show that most of the participants at work, use the hand sanitizer provided by the company a alcoholic solution of 2-propanol 70%. Nearly half of the workers disinfected their hands more than 3 times per day, but at work, there was a concern to also disinfect wrists and forearms. Self-reported dermal effects show that half of the participants noticed skin dryness with the increased use of hand sanitisers. Application: The novelty of this work is posed by the type of sample under study (industrial rather than hospital context) which allow gathering data to build knowledge in this field and to develop guidelines of good practices on how to make adequate disinfection and to promote skin health in industrial settings.