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  • Tuberculosis incidence in solid organ transplant recipients in Europe: A multicenter TBnet cohort study
    Publication . Lange, Berit; Brehm, Thomas Theo; Arend, Sandra M.; Arias-Guillén, Miguel; Bakker, Marleen; Berastegui, Cristina; Babiker, Maaz; Charif, Rawya; Duarte, Raquel; Flick, Holger; Hofland, Regina W.; Ismail, Joanna; Kniepeiss, Daniela; Krepel, Jessica; Krishnan, Nithya; Kuijpers, Dora L.; Kunst, Heinke; van Leth, Frank; Lezaic, Visnja; Los-Arcos, Ibai; Machová, Jana; Milburn, Heather; Morais, Sandra A.; Kon, Onn Min; Osoro-Suarez, Carmen; Pessegueiro Miranda, Helena; Pesut, Dragica; Rahman, Ananna; Reischig, Tomas; Sánchez-Montalvá, Adrián; Spohn, Hanna Elisa; Stegenga, Merel T.; de Vries, Aiko P. J.; Wagner, Dirk; Wobser, Rika; Lange, Christoph; Sester, Martina
    Background: Solid organ transplant (SOT) recipients face elevated tuberculosis risk, yet optimal prevention strategies in low- to medium-incidence regions remain unclear. Methods: We conducted a multicenter retrospective cohort study of adult SOT recipients transplanted between 2007 and 2012 at 15 European centers, with follow-up through 2018. The primary outcome was microbiologically confirmed post-transplant tuberculosis. Incidence rates were calculated per 100,000 person-years; standardized incidence ratios (SIRs) used World Health Organization country-specific background rates. Cox models assessed risk factors. Results: Among 5805 patients (median age 51; 62.7% male; 73.9% renal transplants), 33.8% were tested for tuberculosis infection and 10.3% received tuberculosis preventive therapy (TPT). Over 33,785 person-years, 23 patients (0.4%) developed tuberculosis (68.0/100,000 person-years). Highest incidence occurred in patients with positive screening but no TPT (233.8/100,000). Incidence was higher in Southern vs. Central Europe (251.9 vs. 28.7/100,000), with pooled SIRs of 12.8 and 3.1, respectively. Tuberculosis risk was elevated among Southern European recipients (HR 22.9) and those with migration history (HR 2.7). Conclusion: Tuberculosis risk is increased in European SOT recipients. Regionally adapted prevention strategies, including targeted screening in low-incidence areas and universal screening in higher-incidence regions, are warranted.
    2025-12-20Artigo científico Acesso aberto Ver mais