CD - Apresentações orais em encontros internacionais
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Browsing CD - Apresentações orais em encontros internacionais by Author "Albuquerque, José Maria"
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- Contribution to nanomaterials safety assessment: the need of integrating in vitro, in vivo and in silico strategiesPublication . Silva, Maria João; Louro, Henriqueta; Borges, Teresa; Lavinha, João; Albuquerque, José MariaFundamental and application-driven research in nanotechnology is expected to boost nanoscience and innovation towards development of safe-by-design nanomaterials(NM). In this scenario, adding vast societal benefits, a multi-disciplinary approach to responsible innovation must be undertaken. Although the widespread use of NM, it is not clear whether they impact on environment and human health, on the long-term. Potential deleterious effects, e.g., genotoxicity that is intimately associated with carcinogenicity, have to be assessed using complementary in vitro and in vivo assays, nested within the conventional risk assessment paradigm and considering specific physicochemical properties of NM. In this study we present the testing strategy that was recently applied to the genotoxicity characterization of titanium dioxide nanomaterials in human cells and in an integrative in vivo model. The results supported the view that a thorough understanding of the relationship between the physicochemical properties, the behaviour of NM in biological systems and their mechanism of action is of utmost importance to predict their biological activity. In conclusion, the knowledge gap between nanoscience and hazard assessment has to be filled within a multi-disciplinary approach including experimental and computational components in an iterative process, towards an improved strategy for the safety evaluation of nanomaterials.
- Health System Impact Assessment and the High Level Group on Health Services and Medical CarePublication . Albuquerque, José Maria; Miguel, José PereiraThe High Level Group on Health Services and Medical Care was established by lhe European Commission in 2004 to endorse and implement the recommendations issued from lhe Patient Mobility reflection process. Amongsl lhese, arose lhe need lo develop and explore an assessment on social grounds (along lhe economic and lhe environmental) were lhe impact of non-health EU policies on health systems effectiveness should be delailed. In this paper we review the mandate and role of lhe High Levei Group in putting forward a mechanism specifically addressing Heallh Systems (HS), within the integrated impact assessment current methodology. The proposed model (and assessment tool) is presented and discussed along the key function elements, priorities and objectives of HS in formulating and implemenling EU legislative initiatives and policies.