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Biological impact of metal nanomaterials in relation to their physicochemical characteristics

2019-01-29Journal article Restricted access
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dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSaruga, Andreia
dc.contributor.authorSantos, Joana
dc.contributor.authorPinhão, Mariana
dc.contributor.authorSilva, Maria Joao
dc.date.accessioned2019-03-21T12:25:14Z
dc.date.available2020-05-01T00:30:16Z
dc.date.issued2019-01-29
dc.descriptionCorrigendum to "Biological impact of metal nanomaterials in relation to their physicochemical characteristics" [Toxicol in Vitro. 2019 Jan 29;56:172-183]. [Toxicol In Vitro. 2019]. Toxicol In Vitro. 2019 Feb 16. pii: S0887-2333(19)30110-9. doi: 10.1016/j.tiv.2019.02.001. [Epub ahead of print]. Disponível em: https://www.sciencedirect.com/science/article/pii/S0887233319301109?via%3Dihubpt_PT
dc.description.abstractSeveral metal and metal oxide nanomaterials (NMs), e.g., cerium dioxide NMs(CeO2), barium sulphate NMs(BaSO4) and titanium dioxide NMs(TiO2), display advantageous properties over the bulk materials and have a broad range of innovative applications in food, industry and consumer products. Whether these materials are hazardous and impact on human health or the environment remains an issue that needs to be addressed by reliable studies focused on nano-bio interactions. To contribute to the comprehensive investigation of the toxicological effects of metal NMs, we have assessed the cytotoxic and genotoxic effects of benchmark NMs in human respiratory cells, concomitantly with the analysis of their secondary properties in the cellular moiety. This study shows no effects of BaSO4, while some, but not all, of the other metal-related NMs analyzed have adverse effects. Human respiratory cells were prone to CeO2 cytotoxicity and to DNA damage induction following exposure to anatase TiO2 (NM-100, NM-101 and NM-102), but not rutile TiO2. No clastogenic/aneugenic effects were ascribed to any of the tested NMs. Using correlation analysis, this work also suggests that among these TiO2, the size in the cellular moiety may be the most relevant secondary feature that determines their biological consequences.pt_PT
dc.description.sponsorshipThis work was financed by national funds through the FCT - Foundation for Science and Technology, I.P., under the project PTDC/ SAU-PUB/29481/2017. Research co-funded by European Union Seventh Framework Programme (FP7/2007e2013) under the project NANoREG (A common European approach to the regulatory testing of NMs), grant agreement 310584 and by UID/BIM/00009/2013 (Centre for Toxicogenomics and Human Health – ToxOmics, Foundation for Science and Technology).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxicol In Vitro. 2019 Apr;56:172-183. doi: 10.1016/j.tiv.2019.01.018. Epub 2019 Jan 29pt_PT
dc.identifier.doi10.1016/j.tiv.2019.01.018pt_PT
dc.identifier.issn0887-2333
dc.identifier.urihttp://hdl.handle.net/10400.18/6261
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ European Society for Toxicology in Vitropt_PT
dc.relationA common European approach to the regulatory testing of nanomaterials
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0887233318307239?via%3Dihubpt_PT
dc.subjectNanomaterialspt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectNanotechnologypt_PT
dc.subjectTitanium Dioxidept_PT
dc.subjectCerium Dioxidept_PT
dc.subjectBarium Sulphatept_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleBiological impact of metal nanomaterials in relation to their physicochemical characteristicspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA common European approach to the regulatory testing of nanomaterials
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/310584/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F00009%2F2013/PT
oaire.citation.endPage183pt_PT
oaire.citation.startPage172pt_PT
oaire.citation.titleToxicology in Vitropt_PT
oaire.citation.volume56pt_PT
oaire.fundingStreamFP7
oaire.fundingStream5876
person.familyNameLouro
person.familyNamePinhão
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMariana
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-8774-7435
person.identifier.orcid0000-0002-6060-0716
person.identifier.ridU-8230-2017
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id57191539779
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctPolítica editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscoverya7763685-7c34-468d-b958-9dd0aca66db4
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