Loading...
Publication
Doenças do metabolismo do colesterol: cromatografia de esteróis no diagnóstico de 25 casos em Portugal
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 669.86 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Os esteróis desempenham um papel fundamental nos processos fisiológicos
de praticamente todos os organismos vivos. O esterol mais
abundante nos seres humanos é o colesterol, o qual desempenha uma
multiplicidade de funções desde a estrutural à sinalização. A extração e
análise de esteróis no plasma é complexa devido à sua insolubilidade,
sequestração dentro das lipoproteínas e à grande diferença entre cada
tipo de esterol. Os autores apresentam a casuística referentes à análise
de 13 esteróis e fitosteróis em plasma e líquido amniótico.
Sterols play essential roles in the physiological processes of virtually all living organisms. In Man, the most abundant sterol is cholesterol, which has a myriad of functions in biology, ranging from structural to signaling. The extraction and analysis of sterols in human plasma present a unique challenge due to their virtual insolubility, sequestration within lipoproteins, and dramatic differences in the levels of individual sterols. We present our positive results of the analysis of 13 sterols and phytosterols from human plasma and amniotic fluid in a single GC-MS run.
Sterols play essential roles in the physiological processes of virtually all living organisms. In Man, the most abundant sterol is cholesterol, which has a myriad of functions in biology, ranging from structural to signaling. The extraction and analysis of sterols in human plasma present a unique challenge due to their virtual insolubility, sequestration within lipoproteins, and dramatic differences in the levels of individual sterols. We present our positive results of the analysis of 13 sterols and phytosterols from human plasma and amniotic fluid in a single GC-MS run.
Description
Keywords
Colesterol Doenças do Metabolismo do Colesterol Esteróis Métodos de Diagnóstico Cromatografia de Esteróis Saúde Pública Portugal Cholesterol Synthesis Defects Diagnosis Doenças Genéticas
Pedagogical Context
Citation
Boletim Epidemiológico Observações. 2016 maio-agosto;5(16):33-37
Publisher
Instituto Nacional de Saúde Doutor Ricardo Jorge, IP