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Epidemiology of congenital cerebral anomalies in Europe: a multicentre, population-based EUROCAT study

2019-06-26Journal article Restricted access
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dc.contributor.authorMorris, Joan K.
dc.contributor.authorWellesley, Diana G.
dc.contributor.authorBarisic, Ingeborg
dc.contributor.authorAddor, Marie-Claude
dc.contributor.authorBergman, Jorieke E.H.
dc.contributor.authorBraz, Paula
dc.contributor.authorCavero-Carbonell, Clara
dc.contributor.authorDraper, Elizabeth S.
dc.contributor.authorGatt, Miriam
dc.contributor.authorHaeusler, Martin
dc.contributor.authorKlungsoyr, Kari
dc.contributor.authorKurinczuk, Jennifer J.
dc.contributor.authorLelong, Natalie
dc.contributor.authorLuyt, Karen
dc.contributor.authorLynch, Catherine
dc.contributor.authorO’Mahony, Mary T.
dc.contributor.authorMokoroa, Olatz
dc.contributor.authorNelen, Vera
dc.contributor.authorNeville, Amanda J.
dc.contributor.authorPierini, Anna
dc.contributor.authorRandrianaivo, Hanitra
dc.contributor.authorRankin, Judith
dc.contributor.authorRissmann, Anke
dc.contributor.authorRouget, Florence
dc.contributor.authorSchaub, Bruno
dc.contributor.authorTucker, David F.
dc.contributor.authorVerellen-Dumoulin, Christine
dc.contributor.authorWiesel, Awi
dc.contributor.authorZymak-Zakutnia, Natalia
dc.contributor.authorLanzoni, Monica
dc.contributor.authorGarne, Ester
dc.date.accessioned2020-04-23T16:24:44Z
dc.date.available2020-04-23T16:24:44Z
dc.date.issued2019-06-26
dc.description.abstractObjectives: To describe the epidemiology and geographical differences in prevalence of congenital cerebral anomalies in Europe. Design and setting: Congenital cerebral anomalies (International Classification of Diseases, 10th Revision code Q04) recorded in 29 population-based EUROCAT registries conducting surveillance of 1.7 million births per annum (29% of all European births). Participants: All birth outcomes (live births, fetal deaths from 20 weeks gestation and terminations of pregnancy after prenatal diagnosis of a fetal anomaly (TOPFA)) from 2005 to 2014. Main outcome measures: Prevalence, proportion of associated non-cerebral anomalies, prenatal detection rate. Results: 4927 cases with congenital cerebral anomalies were identified; a prevalence (adjusted for under-reporting) of 9.8 (95% CI: 8.5 to 11.2) per 10 000 births. There was a sixfold difference in prevalence across the registries. Registries with higher proportions of prenatal diagnoses had higher prevalence. Overall, 55% of all cases were liveborn, 3% were fetal deaths and 41% resulted in TOPFA. Forty-eight per cent of all cases were an isolated cerebral anomaly, 25% had associated non-cerebral anomalies and 27% were chromosomal or part of a syndrome (genetic or teratogenic). The prevalence excluding genetic or chromosomal conditions increased by 2.4% per annum (95% CI: 1.3% to 3.5%), with the increases occurring only for congenital malformations of the corpus callosum (3.0% per annum) and 'other reduction deformities of the brain' (2.8% per annum). Conclusions: Only half of the cases were isolated cerebral anomalies. Improved prenatal and postnatal diagnosis may account for the increase in prevalence of congenital cerebral anomalies from 2005 to 2014. However, major differences in prevalence remain between regions.pt_PT
dc.description.sponsorshipFunding for the JRC-EUROCAT Central Registry is described in ’A sustainable solution for the activities of the European network for surveillance of congenital anomalies’. EUROCAT registries are funded as described in: EUROCAT Member Registries: Organization and Processes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArch Dis Child. 2019 Dec;104(12):1181-1187. doi: 10.1136/archdischild-2018-316733. Epub 2019 Jun 26.pt_PT
dc.identifier.doi10.1136/archdischild-2018-316733pt_PT
dc.identifier.issn0003-9888
dc.identifier.urihttp://hdl.handle.net/10400.18/6497
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.relation.publisherversionhttps://adc.bmj.com/content/104/12/1181pt_PT
dc.subjectEpidemiologypt_PT
dc.subjectCongenital Abnormpt_PT
dc.subjectRENACpt_PT
dc.subjectAnomalias Congénitaspt_PT
dc.subjectEUROCATpt_PT
dc.subjectObservação em Saúde e Vigilânciapt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.titleEpidemiology of congenital cerebral anomalies in Europe: a multicentre, population-based EUROCAT studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1187pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1181pt_PT
oaire.citation.titleArchives of Disease in Childhoodpt_PT
oaire.citation.volume104pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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