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Orientador(es)
Resumo(s)
Sickle-cell disease (SCD) is a clinically heterogeneous autosomal recessive monogenic chronic
anaemia characterized by recurrent episodes of severe vaso-occlusion, haemolysis and infection.
Painful crises are the major SCD clinical manifestation probably due to significant increase in
dense red blood cells (RBC) and reduction of their ability to pass through capillaries. Using
proteomic strategies, we aim to discover novel and better SCD prognosis biomarkers as early
predictors of the transition from steady-state to crisis namely vaso-occlusive episodes, thus,
allowing a prompt and specific therapeutic intervention
Descrição
Palavras-chave
SCD Plasma Proteome Genómica Funcional e Estrutural