Marques, Ana RitaMartiniano, HugoRomão, LuísaM. Vicente, Astrid2017-12-122017-12-122017-01http://hdl.handle.net/10400.18/4848Objectives: The aim of this project is to understand the role of epigenetic factors in ASD, with a particular focus on long noncoding lncRNA, miRNA and other regulatory molecules. For this purpose this project has two main specific objectives: 1. To identify lncRNA and miRNA loci implicated in ASD through the analysis of two large datasets with CNV and SNV data from ASD families and controls; 2. To identify genetic variants and modulating epigenetic factors that could lead to differential disease expression by exploring multiplex families in which ASD co-occurs with other NPDs.engAutism Spectrum DisorderPerturbações do Desenvolvimento Infantil e Saúde Mentalconference object