Sassetti, M.Zé-Zé, L.Franco, J.Cunha, J.D.Gomes, A.Tomé, A.Alves, M.J.2019-02-182019-02-182018-10-01Trans R Soc Trop Med Hyg. 2018 Oct 1;112(10):458-462. doi: 10.1093/trstmh/try0740035-9203http://hdl.handle.net/10400.18/5843Background: Zika virus has been responsible for recent outbreaks in the western hemisphere with known neurological complications such as microcephaly. This complication has not been previously documented in continental Africa. Methods: Neurological evaluation of the newborn was performed after birth, at one and two months of age. The mother and the newborn sera samples were tested by immunofluorescent assay (IFA; immunoglobulin G [IgG] and IgM) for Zika virus and the presence of Zika virus ribonucleic acid (RNA) was checked by qualitative real-time reverse transcription polymerase chain reaction (RT-PCR) in placenta, blood and urine samples. Results: We report on a newborn, born in Portugal, with microcephaly with confirmed congenital Zika virus infection (Asian lineage) imported from Angola with typical clinical and imaging findings. Conclusions: To our knowledge this is the first report that shows the circulation of the Asian lineage in Angola and the first report of a congenital Zika syndrome in continental Africa.engZika VirusAngolaCongenital Zika SyndromeMicrocephalyPortugalInfecções Sistémicas e Zoonosesjournal article10.1093/trstmh/try074