Domingues-Montanari, S.Fernández-Cadenas, I.Del Rio-Espinola, A.Corbeto, N.Krug, T.Manso, H.Gouveia, L.Sobral, J.Mendioroz, M.Fernández-Morales, J.Alvarez-Sabin, J.Ribó, M.Rubiera, M.Obach, V.Martí-Fàbregas, J.Freijo, M.Serena, J.Ferro, J.M.Vicente, A.M.Oliveira, S.A.Montaner, J.2011-09-142011-09-142010-05Cerebrovasc Dis. 2010;29(6):528-37. Epub 2010 Mar 30.1015-9770DOI: 10.1159/000302738http://hdl.handle.net/10400.18/172Variants in the 5-lipoxygenase-activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) genes have first been associated with ischemic stroke (IS) through whole-genome linkage screens. However, association studies obtained conflicting results. We aimed to investigate the contribution of selected single nucleotide polymorphisms (SNPs) in these genes for the first time in a large Iberian population.engALOX5APSingle nucleotide polymorphismMeta-analysisStrokeGeneticsPDE4DDoenças Cardio e Cérebro-vascularesAssociation of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional studyjournal article