Almeida, L.S.Nogueira, C.Vilarinho, L.2012-10-242012-10-242012In Skeletal Muscle- From Myogenesis to Clinical Relations. 2012: 293-316978-953-51-0712-5http://hdl.handle.net/10400.18/1055The focus of this chapter is to review the clinical and molecular etiologies of nuclear defects involved in mtDNA stability and in mitochondrial protein synthesis. The overview done here will hopefully provide insights towards best diagnostic strategies of mitochondrial cross–talk disorders, being useful for clinicians when facing similar cases. Additionally we will present a diagnostic algorithm for these diseases based on our knowledge.engIntergenomic Communication disordersmtDNADoenças Genéticasbook part