Candeias, Marco M.Ohki, Rieko2021-03-182021-03-182020-05-17Int J Mol Sci. 20(2). Special Issue.1422-0067http://hdl.handle.net/10400.18/7542Special Issue Editors (Guest Editors): Marco M. Candeias (Molecular and RNA Cancer Unit, Kyoto University, Graduate School of Medicine, Japan; Molecular and RNA Cancer Unit, Departamento de Genética Humana, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisboa, Portugal) and Rieko Ohki (Laboratory of Fundamental Oncology, National Cancer Center Research Institute, Japan). https://www.mdpi.com/journal/ijms/special_issues/p53_40A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry". Publicação disponível em: https://www.mdpi.com/1422-0067/21/2?listby=date&view=defaultThe “p53 team” dictates cell fate and sacrifices cell life as demanded, for the greater good of the organism. The p53 team consists of its close family (p53, p63, and p73 genes), a varied number of isoforms, and a plethora of downstream target genes. Together they control cell stemness, division, chromosome integrity, epigenetics, differentiation, senescence and death; response to stress, infection and disease; reproduction, immunity, metabolism, and regeneration. As a consequence, p53 team function is central to our lives, from birth and development to aging and life span in both health and disease. Forty years after its discovery, we aim to cover important and new aspects of p53 and its team, not only in cancer, but in all the diversity of p53-dependent activities. Authors are invited to review recent work or submit original research in all areas of recent and current p53 research, with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms.engp53 mRNACancerGenómica Funcional e EstruturalDoenças Genéticasother