Tavares, IsabelOliveira, Márcia E.Maia, NunoMoreira, LucianaCastro Lacerda, PedroSantos, JosefinaSantos, RosárioPinho Costa, PauloLobato, Luísa2020-05-072020-05-072019-07-25Amyloid . 2019;26(sup1):144-145. doi: 10.1080/13506129.2019.1582500. Epub 2019 Jul 251350-6129http://hdl.handle.net/10400.18/6609Background: Fibrinogen A alpha-chain (AFib) amyloidosis is an autosomal dominant disease with an endemic foci in the district of Braga, northern Portugal [1]. Among the 16 amyloidogenic mutations identified in the fibrinogen A alpha-chain gene (FGA) [2,3], the c.1634A > T (p.Glu545Val) mutation (rs121909612) is the most common and, so far, the only one identified in Portugal. A first study using three common polymorphisms showed a single haplotype, associated with the FGA p.Glu545Val mutation in Irish–American and Polish–Canadian kindreds [4]. However, the origin of this amyloidogenic variant in diverse regions and its migration in the different populations are still unclear. Therefore, we proceeded to a preliminary study using two FGA haplotype markers in newly identified Portuguese and Brazilian carriers to investigate the possibility of a common ancestor.engAmino Acid SubstitutionAmyloidosisBrazilFemaleFibrinogenHumansMalePortugalFamilyHaplotypesMutation, MissensePolymorphism, GeneticDoenças Genéticasjournal article10.1080/13506129.2019.1582500