Pádua, E.Rodés, B.Pérez-Piñar, T.Silva, A.F.Jiménez, V.Ferreira, F.Toro, C.2016-10-062016-10-062011-03AIDS Res Hum Retroviruses. 2011 Mar;27(3):317-22. doi: 10.1089/aid.2010.0195. Epub 2010 Oct 180889-2229http://hdl.handle.net/10400.18/4036Over the past decade, Portugal and Spain received large numbers of immigrants from HTLV-1 endemic areas. Our aim was to investigate the diversity of subtypes circulating in these two countries and the introduction of new variants. We performed a molecular analysis of HTLV-1 strains in patients diagnosed since 1998. LTR and env proviral sequences from 26 individuals were analyzed to generate phylogenetic trees along with reference HTLV-1 subtypes from several geographic origins. Epidemiological and clinical data were recorded. Most subjects were immigrants (57.7%) from South America and Africa. All isolates belonged to the cosmopolitan A subtype. Most carried the transcontinental subgroup A, but five subjects carried subgroup D and one carried subgroup C, previously unreported in Europe. HTLV strains showed separate clusters linked to the patients' geographic origin. Although subjects with HTLV-1 infection tend not to be engaged in high-risk practices, silent dissemination of a broad diversity of HTLV-1 viruses may still occur.engHTLV-1SubtypingPortugalSpainInfecções Sexualmente Transmissíveisjournal article10.1089/aid.2010.0195