Laranjeira, MateusOliveira, JorgeSantorelli, FilippoMarchese, MariaNogueira, Célia2026-03-022026-03-022025-07-01http://hdl.handle.net/10400.18/11017Background: ACAD9 is a mitochondrial protein involved in fatty acid β-oxidation and complex I assembly. Mutations in ACAD9 are associated with mitochondrial diseases (MD) of variable severity. Zebrafish (Danio rerio), with conserved mitochondrial physiology and genetic similarity to humans, is a valuable model for assessing the functional impact of variants of uncertain significance (VUS) in MD-related genes.engMitochondrial DiseasesMorpholino OligonucleotidesZebrafishVariants of Unknown SignificanceRescue ExperimentsDoenças Genéticasconference object