Martins, J.M.Fraga, M.Miguens, J.Tortosa, F.Marques, B.Sousa, A.D.2017-11-102018-05-122017-05-11Andrologia. 2017 Dec;49(10). doi: 10.1111/and.12831. Epub 2017 May 11.0303-4569http://hdl.handle.net/10400.18/4831Disorders of sex development generally present in the neonatal period with ambiguity of external genitalia. We report a very old male patient presenting at 75 years because of panhypopituitarism and a large nonsecreting pituitary macroadenoma secondary to long-standing primary hypogonadism due to 46,XX sex reversal disorder now first diagnosed. Sex development disorders may go unrecognised for the entire life span, despite infertility and long-standing primary gonadic failure may lead to uncommon complications.engNeonatal HypogonadismPituitary Gonadotrophic AdenomaSex ReversalDoenças GenéticasGenética Humanajournal article10.1111/and.12831