Host factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosis

Santos, J.A.Duarte, R.Nunes, C.2021-03-312021-03-312020-12-13Pulmonology. Nov-Dec 2020;26(6):353-362. doi: 10.1016/j.pulmoe.2019.11.001. Epub 2019 Dec 13.2531-0437http://hdl.handle.net/10400.18/7616Information on host factors that contribute to false negative and indeterminate results in interferon-γ release assays (IGRA) are critical to improve the usefulness of these tests in the fight against tuberculosis (TB) epidemics. The aim of this study was to estimate and compare the sensitivity of an IGRA and the tuberculin skin test (TST), independently and as a combined approach, in patients with TB and to identify risk factors associated with false negative and indeterminate IGRA results.engInterferon-gamma ReleaseTestsLatent TuberculosisPreventive MedicinePublic HealthTuberculin TestTuberculosisInfecções RespiratóriasHost factors associated to false negative and indeterminate results in an interferon‐γ release assay in patients with active tuberculosisjournal article10.1016/j.pulmoe.2019.11.001